Registration Dossier
Registration Dossier
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EC number: 255-280-9 | CAS number: 41253-21-8
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study (OECD 471) with acceptable restrictions. For further information please refer to ECHA disseminated dossier.
Data source
Reference
- Reference Type:
- other: ECHA disseminated dossier
- Title:
- No information
- Year:
- 2 005
- Bibliographic source:
- ECHA disseminated dossier CAS 41253-21-8 query date 2014-11-20
- Report date:
- 2005
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Deviations:
- yes
- Remarks:
- 2-anthramine was the only positive control compound used to test the efficacy of the S9 fraction
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 1H-1,2,4-triazole, sodium salt
- EC Number:
- 255-280-9
- EC Name:
- 1H-1,2,4-triazole, sodium salt
- Cas Number:
- 41253-21-8
- Molecular formula:
- C2H3N3.Na
- IUPAC Name:
- sodium 1,2,4-triazol-1-ide
Constituent 1
Results and discussion
Test results
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- other: see ECHA disseminated dossier
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
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