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Diss Factsheets
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EC number: 207-431-5 | CAS number: 470-82-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
The results of the in vitro gene mutation studies in bacteria and in vitro chromosome aberration study in mammalian cells concluded that the test substance was not genotoxic.
An in vitro sister chromatid exchange assay indicated that the test material was positive without metabolic activation but negative with metabolic activation, however the results were positive only without activation at doses that induced cell cycle delay. No aberration induction was detected.
Finally, an in vivo mouse micronucleus study was conducted according to OECD guideline 474 on a structural analogue. Since the test substance did not cause any substantial increase in the incidence of micronucleated polychromatic erythrocytes, it is concluded that the test substance did not show any evidence of causing chromosome damage when administered orally in an in vivo test.
Justification for selection of genetic toxicity endpoint
The results of an in vivo mouse micronucleus conducted according to OECD guideline 474 on a structural analogue did not show any evidence of causing chromosome damage when administered orally.
Short description of key information:
In vitro gene mutation studies in bacteria concluded that the test substance was not genotoxic under the conditions of the studies either with or without metabolic activation.
An in vitro chromosome aberration study in mammalian cells concluded that the test substance was not genotoxic under the conditions of the study as the results were negative both with and without metabolic activation.
In a sister chromatid exchange assay, however, the test material was positive without metabolic activation but negative with metabolic activation in a test for genotoxicity. The results were positive only without activation at doses that induced cell cycle delay. No aberration induction was detected.
Finally, the results of an in vivo mouse micronucleus conducted according to OECD guideline 474 on a structural analogue did not show any evidence of causing chromosome damage when administered orally.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
The results of an in vivo mouse micronucleus conducted according to OECD guideline 474 on a structural analogue did not show any evidence of causing chromosome damage when administered orally.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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