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EC number: 215-958-7 | CAS number: 1461-22-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 23 December 1982 to 12 January 1983
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study conducted in accordance with generally accepted scientific principles, possibly with incomplete reporting or methodological deficiencies, which do not affect the quality of the relevant results.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- See principles of method if other than guideline
- Principles of method if other than guideline:
- Deviations from the Protocol:
The proposed dates of completion and submission of the report had to be postponed because of the further administration of additional doses of the test material - GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Tributyltin chloride
- EC Number:
- 215-958-7
- EC Name:
- Tributyltin chloride
- Cas Number:
- 1461-22-9
- Molecular formula:
- C12H27ClSn
- IUPAC Name:
- tributylstannanylium chloride
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Tif: RAIf (SFF)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 7-8 weeks
- Weight at study initiation: 180-218 g
- Fasting period before study: Prior to dosing, the animals were fasted overnight.
- Housing: The animals were kept under conventional laboratory conditions. They were caged in groups of 5 in Macrolon cages type 3 with standardised soft wood bedding (Societe Parisienne des sciures, Pantin).
- Diet: provided ad libitum.
- Water: Water was provided ad libitum.
- Acclimation period: nda
ENVIRONMENTAL CONDITIONS
- Temperature: 22 ± 3 °C
- Humidity: 55 ± 15 %
- Air changes: approximately 15 air changes/h.
- Photoperiod: 12 hours light/day
- The rat has been selected for this test as being a standard species for the determination of an acute oral LD50.
- Animal ID: by colour code using picric acid.
- The animals were allocated to the different dose groups by random selection.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- polyethylene glycol
- Details on oral exposure:
- nda
- Doses:
- 50, 100, 150, 225, 350 mg/kg
- No. of animals per sex per dose:
- 5 males and 5 females (50 in total)
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days or until all symptoms have disappeared, whichever lasts longer.
- Frequency of observations: Daily
- Frequency of weighing: on days 1, 7, 14 and at death
- Necropsy of survivors performed: yes
Spontaneously dying animals were submitted to a gross necropsy as soon as possible; survivors at the end of the observation period. - Statistics:
- From the body weights, the group means and their standard deviations were calculated.
Where feasable, the LD50 including the 95 % confidence limit were computed by the logit method.
Results and discussion
- Preliminary study:
- n/a
Effect levelsopen allclose all
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 101 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 51 - <= 137
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 101 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 37 - <= 153
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 113 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 24 - <= 189
- Mortality:
- See Table 1.
- Clinical signs:
- other: Dyspnoea, exophthalmus, ruffled fur and curved body position are symptoms commonly seen during the observation time following administration of substances by,gavage. In addition, the test material induced the following symptoms: - diarrhoea, which duratio
- Gross pathology:
- At necropsy, dilatation of parts of the digestive tract (small intestine, large intestine) was found by most of the mortally intoxicated rats in the four higher dose groups. This was not observed by the animals which recovered before terminal sacrifice.
- Other findings:
- nda
Any other information on results incl. tables
The 17 animals recovered within 13 days.
According to the Company Standard the test material has a medium acute toxicity when administered orally to the albino rat.
Applicant's summary and conclusion
- Interpretation of results:
- other: EU Criteria: Category 3, Toxic if swallowed
- Conclusions:
- Upon an acute oral administration and a 14 day post-treatment observation period, the following LD50's were determined for the test material: Male rats - 101 mg/kg bw, Female rats - 113 mg/kg bw and Both sexes - 101 mg/kg bw.
- Executive summary:
In an acute oral study in the rat the LD50's for the test material were determined to be 101, 113 & 101 mg/kg bw for males, females and both sexes respectively. According to EU interpretation this test material is classed a toxic.
The symptoms observed include Dyspnoea, exophthalmus, ruffled fur and curved body position. Other symptoms ovserved include diarrhoea, salivation and sedation.
At necropsy, dilatation of parts of the digestive tract (small intestine, large intestine) was found by most of the mortally intoxicated rats in the four higher dose groups. This was not observed by the animals which recovered before terminal sacrifice.
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