Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-690-6 | CAS number: 124-22-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_ecotoxicological-information.png)
Endpoint summary
Administrative data
Description of key information
Additional information
Toxicity to soil macro organisms
Acute toxicity
Noack (1999) determined the acute effects of tallow alkyl amine on earthwormEisenia fetidaaccording to OECD Guideline 207. Different concentrations of tallow alkyl amine (100, 180, 320, 580, 1000 mg/kg dry weight) were applied once at the beginning of the test. No significant mortality was observed in any of the tested concentrations after 14 days of exposure. As test result a LC50 > 1000 mg/kg dry weight was obtained from this study.
Long-term toxicity
The effects of amines, hydrogenated tallow (Armeen HT) on mortality, biomass and reproduction of Eisenia fetida were tested according to OECD 222 under a static exposure for56 days (Noack, 2006). Natural soil (Lufa 2.2) was used as substrate, and the different concentration of the substance mixed with the substrate. The concentrations applied were 50, 100, 200, 500, and 1,000 mg/kg soil dry weight. In addition tests using control and vehicle control were performed.
The test is valid without restrictions and the results are reliable. After 28 days of exposure, no effects on survival of the adult worms were observed in all concentrations. After the following four weeks, the reproduction rate (average number of juveniles) was significantly reduced in the concentrations of 500 and 1,000 mg/kg soil compared to the control. Hence, the LOEC is 500 mg/kg soil and the NOEC 200 mg/kg soil.This NOEC can be used as a chronic endpoint representing heterotrophs (consumer) in the terrestrial environment.
Toxicity to terrestrial plants
Two acute studies have been performed on terrestrial organisms (plants and earthworms) using both tallow alkyl amine (Genamin TA 100 D) as test substance:
The growth test with terrestrial plants was conducted according to the OECD Guideline 208 by Noack (2000). Test systems were a monocotyledon (oat) and two dicotyledons (red clover and radish). Seeds of each plant were exposed to different concentrations of tallow alkyl amine (1, 10, 100 mg test item per kg soil dry weight) and a control. No vehicles were used to dissolve the test substance. The toxic effects of the soil incorporated test item on the emergence of seedlings and the early stages of growth were determined by visual observations and dry weight determination. No phytotoxic effects were observed throughout the test in all replicates resulting in a LC50 (emergence) and a EC50 (growth) of > 100 mg/kg dw.As no effect on growth and emergence for all three species was observed at the highest concentration of 100 mg/kg dw. the NOEC is > 100 mg/kg dw. as well. The NOEC can be used as a chronic endpoint representing autotrophs (producer) in the terrestrial compartment.
7.2.1.3Toxicity to soil micro-organisms
Measured data on the toxicity to soil microorganisms are not available. But read across to the quat N-(C12-14) alkyl, N-Hydroxyalkyl, N,N-dimethylammonium chloride (HYEQS) (Clariant, 2009) can be done. HYEQS has similar sorption properties when compared to the Primary alkyl amines. In the OECD 209 test of sludge respiration inhibition (Clariant, 2010a) HYEQS has a EC10 of 4 mg/L and in the OECD 216 Soil microorganism test a NOEC of > 1000 mg/kg soil dw. (Clariant, 2010a).Cocoalkyl amines having a carbon distribution with a maximum at C12-C14 has a EC10 of 5.5 mg/L in the OECD 209 test (see Table 7.4.1-1). Based on these facts a NOEC of 1000 mg/kg dw. for soil micro-organisms can be justified forCocoalkyl amine in a read across approach as well. This NOEC can be used as a chronic endpoint representing detritivors (decomposers) in the terrestrial compartment.
Toxicity to other terrestrial organisms
The results of three studies of the nematodical effect of primary fatty amines on three different species of nematode are summarized in table 3.2.9. The tests were carried out under comparable conditions at 37°C in NaCl solution. The EC100 values determined withAncylostoma canniumreveal an increasingly toxic effect with increasing chain length of the fatty amines (Ishizuka et al. 1971).
Table:Nematodical effect of primary fatty amines (test conditions 37°C, NaCl-solution)
Species |
effect [mg/l] |
C8 |
C10 |
C12 |
C16 |
C18 |
Reference |
Toxocara canis(larvae) (dog ascarid) |
3h-EC100 |
- |
79 |
- |
- |
- |
Kiuchi et al. 1987 |
Ancylostoma cannium(larvae) (dog hookworm) |
24h-EC100 |
200 |
200 |
6.25 |
3.13 |
1.6 |
Ishizuka et al.(1971) |
Ascaris lumbricoides(human ascarid) |
1h-EC0 |
- |
1000 |
- |
- |
- |
Anderson and Hurwitz (1953) |
Nagase et al. (1982) exposed the nematodeBursaphelenchus lignicolusto different fatty amines in an aqueous test solution for 24 hours at 25°C (100 worms/ml; amine concentration 10 E-3 – 10 mmol/l; at chain lengths of and above 14 C atoms using solubilizer). The toxic effect on the nematodes increased from octylamine (24h-LC50 = 15.5 mg/l) to decylamine (24h-LC50 = 11.8 mg/l) and then remained constant for the longer chain homologous at 24h-LC50 = 2.1-2.3 mg/l.
However, as unsuitable test systems were used, the test results obtained forAncylostoma canniumandBursaphelenchus lignicoluscan only give a rough indication of the nematodical effect of primary fatty amines and are therefore not used for the further assessment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)