Disodium 2-(2,4,5,7-tetrabromo-6-oxido-3-oxoxanthen-9-yl)benzoate

Density

Link to relevant study record(s)

Reference

Endpoint:

density, other

Remarks:

pour density; tap density

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2016-11-24 – 2016-11-24

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

test procedure in accordance with national standard methods

Justification for type of information:

Experimental methods usingstandard methods of analysis

Qualifier:

according to guideline

Guideline:

OECD Guideline 109 (Density of Liquids and Solids)

Principles of method if other than guideline:

The density is calculated from the difference in weight between the full and empty pycnometer and its volume

GLP compliance:

no

Type of method:

pycnometer method

Key result

Type:

pour density

Density:

0.781 g/cm³

Temp.:

27.05 °C

Remarks on result:

other: No other detail available

Key result

Type:

tap density

Density:

0.97 g/cm³

Temp.:

27.05 °C

Remarks on result:

other: No other detail available

TEST ITEM DESCRIPTION AND RESULTS

FOR SOLIDS:

By Pour Density and Tapped Density Method:

Method Details		Observations		Remarks if, any
Guideline	OECD 109	1^stReading	2^nd Reading
Method	Test methods: Pour density and tapped density of powders” recommended in The International Pharmacopoeia, Fourth Edition, 2014
Principle of method	Pour Density: It is the ratio of known weight of test item and its volume in graduated glass cylinder.   Tap Density: It is the difference between the volume of test item measured before & after tapping in the graduated glass cylinder.
Test temperature (°C)	-	26.9	27.2
Atmospheric pressure (in hPa)	-	978.4	978.6
Weight of test item(m)		20.342	20.289
Volume of measuring cylinder; readability in g		250 ml ;2 ml	250 ml ;2 ml
Volume of test item without tapping (V)		26 ml	26 ml
Volume of test item after tapping ( V1)	After 10 tapping After 50 tapping After 100 tapping After 250 tapping After 500 tapping After 750 Tapping	20 ml - - - - -	20 ml - - - - -

 

CALCULATION

FOR SOLIDS:

By Pour Density and Tapped Density Method

 

Parameters	Details	Calculated values		Average Density
		1st Calculation	2nd Calculation
Pour Density of test Item(g/cm³)	= m/v	20.342 /26=0.7823	20.289/26 =0.7803	0.7813 g/cm3
Tap density of test Item(g/cm³)	= m/v	20.342 /20=1.017	20.289/22=0.9222	0.9696 g/cm3

 

Conclusions:

The density of test chemical was determined following OECD Guideline 109 and according to the Pour density and tapped density of powders” recommended in The International Pharmacopoeia, Fourth Edition, 2014 using bulk density apparatus. The pour density and tapped density of test item is was determine to be 0.7813 g/cm³ and 0.9696 g/cm³ at 27.05°C and 978.5 hPa.

Executive summary:

The density of test chemical was determined following OECD Guideline 109 and according to the Pour density and tapped density of powders” recommended in The International Pharmacopoeia, Fourth Edition, 2014 using bulk density apparatus. The pour density and tapped density of test item is was determine to be 0.7813 g/cm³ and 0.9696 g/cm³ at 27.05°C and 978.5 hPa.

Description of key information

The density of test chemical was determined following OECD Guideline 109 and according to the Pour density and tapped density of powders” recommended in The International Pharmacopoeia, Fourth Edition, 2014 using bulk density apparatus. The pour density and tapped density of test item is was determine to be 0.7813 g/cm³ and 0.9696 g/cm³ at 27.05°C and 978.5 hPa.

Additional information

The density of test chemical was determined following OECD Guideline 109 and according to the Pour density and tapped density of powders” recommended in The International Pharmacopoeia, Fourth Edition, 2014 using bulk density apparatus. The pour density and tapped density of test item is was determine to be 0.7813 g/cm³ and 0.9696 g/cm³ at 27.05°C and 978.5 hPa.