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Diss Factsheets
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EC number: 944-710-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Endpoint summary
Administrative data
Description of key information
Only slight transient effects were recorded after a single oral dose of 5000 mg/kg bw in rats
no mortality at 5000 mg/kg bw.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1975
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: early study, before GLP, short report, that contains the main details of the performed test, limited substance data
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- controls included, high dose and application volume
- GLP compliance:
- no
- Remarks:
- pre-dates GLP-regulation
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- other: CFY
- Sex:
- male/female
- Route of administration:
- oral: gavage
- Vehicle:
- other: aqueous gum tragacanth (0.5%)
- Details on oral exposure:
- prepared as a 20% suspension in aqueous gum tragacanth (0.5%) and administered by oral intubation at a dosage volume of 25 ml/kg bodyweight
- Doses:
- 0 (control) or 5000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- ca. 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- none
- Clinical signs:
- other: lethargy, piloerection, diuresis, diarrhoea and a slight increase in salivation. Blue stained urine and faeces were observed from all rats.
- Gross pathology:
- no relevant findings
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute median lethal oral dose (LDso) to rats of the test item was found to be: greater than 5000 mg/kg bodyweight.
- Executive summary:
Rats of the CFY strain, in the weight range 140 to 186 g were starved overnight before treatment with the test item.
The test item was prepared as a 20% suspension in aqueous gum tragacanth (0.5%) and administered by oral intubation at a dosage volume of 25 ml/kg bodyweight.
Rats treated with the vehicle alone (25 ml/kg) served as controls.
During the observation period of 14 days, a record was kept of all signs of toxicity. All rats were sacrificed terminally and examined macroscopically in an attempt to identify any target organs.
RESULTS
Ten rats (five male and five female) were treated with the test item at a dosage level of 5000 mg/kg bodyweight .
There were no mortalities.
Signs of reaction to treatment, observed shortly after dosing, consisted of lethargy, piloerection, diuresis, diarrhoea and a slight increase in salivation. Blue stained urine and faeces were observed from all rats. Recovery of all animals, as judged by external appearance and behaviour, was apparently complete within four days of treatment.
Bodyweight gains of all rats were within normal limits and terminal autopsy findings were normal.
CONCLUSION
The acute median lethal oral dose (LD50) to rats of the test item was found to be: greater than 5000 mg/kg bodyweight.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- 2 valid with restrictions
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Only slight transient effects were recorded after a single oral dose of 5000 mg/kg bw in rats
Justification for selection of acute toxicity – oral endpoint
only available study
Justification for classification or non-classification
no classification
no mortality at 5000 mg/kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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