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EC number: 270-735-1 | CAS number: 68477-50-9 A complex combination of hydrocarbons obtained from the distillation of polymerized steam-cracked petroleum distillate. It consists predominantly of hydrocarbons having carbon numbers predominantly in the range of C5 through C12.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Carcinogenicity
Administrative data
Description of key information
There are no specific carcinogenicity data on any of the streams within this category however, there are data on the carcinogenicity of a number of specific components present in the streams. As all streams contain >=1% isoprene which is a category 2 genotoxic carcinogen (DPD), classification of all category streams is based on isoprene. Additional classification is required for streams containing >=0.1% benzene which is classified as a category 1 carcinogens (DPD).
Key value for chemical safety assessment
Justification for classification or non-classification
Isoprene is present at >=1% in all streams and therefore mandatory classification as Carcinogen Cat 2 R45 under DPD with corresponding classification as Category 1B, H350 under CLP is required for all C5 non-cyclics streams.
CAS numbers 68476-55-1 and 91995-41-4 are listed in Annex VI of CLP and are classified as follows Carcinogenic Cat 2, R45 according to Dir 1999/45/EC and Cat 1B, H350 under CLP Reg (EC) 1272/2008.
CAS number 68477-35-0 is listed in Annex VI of CLP and is classified as follows Carcinogenic Cat 1, R45 according to Dir 1999/45/EC and Cat 1B, H350 under CLP Reg (EC) 1272/2008.
It is proposed that the remaining C5 non-cyclics stream (CAS 68476-43-7) should be classified as follows:Carcinogenic Cat 2, R45 according to Dir 1999/45/EC and Cat 1B, H350 under CLP Reg (EC) 1272/2008.
If benzene is present at >= 0.1% the classification should be May cause cancer Carcinogenic Cat 1, R45 according to Dir 1999/45/EC and Cat 1A, H350 under Reg (EC) 1272/2008.
Additional information
There are no carcinogenicity data for any of the streams identified in the C5 non-cyclics category. Specific components that have been identified as present in some streams and shown to be carcinogenic are the marker substance, isoprene, as well as benzene, which is present in some but not all streams.
Isoprene (Classification: EU - Toxic T, Carcinogen Cat 2 R45; CLP - Category 1B, H350): When inhaled in concentrations of 70 ppm (195 mg/m3) and above, isoprene was found to induce tumours in a range of tissues including lung, liver, Harderian gland, forestomach, lymphoreticular system of male mice and in the Harderian gland and pituitary gland of female mice. No statistically significant increases in tumours were reported at a dose level of 10 ppm (28 mg/m3) (Placke et al., 1996). Inhalation by rats of concentrations above the lowest tested value of 220 ppm (613 mg/m3) caused a significantly increased incidence of mammary gland, testicular and kidney tumours in males, and mammary gland tumours in females (NTP, 1999). At the lowest dose tested, 220 ppm (613 mg/m3), a statistically significant increase in only mammary gland fibroadenoma was observed in females.
Benzene (Classification: EU - Toxic T, Carcinogen Cat 1 R45; CLP - Category 1A, H350): Long term experimental carcinogenicity bioassays have shown that benzene is a carcinogen producing a variety of tumours in animals (including lymphomas and leukaemia). Human epidemiological studies indicate a causal relationship between benzene exposure and acute non- lymphatic leukaemia (Crump, 1994; Glass et al, 2003, 2004, 2006; Rinsky et al, 2002; Schnatter, 2004; 2012).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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