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Diss Factsheets
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EC number: 947-217-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 19 January 2017 to 27 January 2017
- Reliability:
- 1 (reliable without restriction)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- soil/sewage sludge
- Radiolabelling:
- no
- Test temperature:
- 30 °C
- Details on study design: HPLC method:
- PREPARATION OF THE DEAD TIME SOLUTION
- The dead time was determined by measuring the retention time of formamide (purity quoted by supplier: 99.94%) at 666 mg/L in methanol.
PREPARATION OF REFERENCE STANDARD SOLUTIONS
- Solutions of reference standards were prepared in methanol as shown in Table 1 (below).
PREPARATION OF THE SAMPLE SOLUTION
- Test item (0.4885 g) was diluted to 10 mL tetrahydrofuran to give a concentration of 48.9 g/L.
DETERMINATION OF RETENTION TIME
- The sample, dead time and reference standard solutions were injected in duplicate using the High Performance Liquid Chromatography (HPLC) parameters shown in the table below.
- The mobile phase was ramped to 100 % tetrahydrofuran shortly after the elution of the last reference standard in order to elute any highly retained test item components. This was carried out for the sample and sample blank injections only.
CALCULATION OF CAPACITY FACTORS
- Capacity factors were determined using the equation k’ = (tr – t0) / t0 where k’ = capacity factor; tr = retention time (min); t0 = dead time (min)
CONSTRUCTION OF THE CALIBRATON CURVE
- A correlation of Log10 k' versus log10 Koc of the reference items was plotted using linear regression (see Figure 1, attached).
- The Log10 Koc values of the reference standards were those quoted in OECD Method 121.
ADSORPTION COEFFICIENT
- The Log10 Koc value was calculated using the equation Log10 Koc = (Log10 k’ – A) / B where Koc = adsorption coefficient; k’ = capacity factor; A = intercept of the calibration curve; B = slope of the calibration curve. - Key result
- Type:
- log Koc
- Value:
- > 5.63 dimensionless
- pH:
- 6.3
- Temp.:
- 30 °C
- Details on results (HPLC method):
- - Typical chromatographs are presented in Appendix 1 (attached).
- The retention times of the dead time and the retention times, capacity factors and Log10 K0c values for the reference standards are shown in Table 2 (attached).
- The calibration curve from which the sample results were taken is presented in Figure 1 (attached).
- The retention times, capacity factors and Log10 Koc values for the sample are shown in Table 3 (below). - Validity criteria fulfilled:
- yes
- Conclusions:
- The adsorption coefficient of the test item was determined to be > 4.27 x 10E05 with Log10 Koc > 5.63.
- Executive summary:
GUIDELINE
The determination was carried out using the HPLC screening method, designed to be compatible with Method C.19 Adsorption Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 121 of the OECD Guidelines for Testing of Chemicals, 22 January 2001. The test utilised a High Performance Liquid Chromatograph. A commercially available cyanopropyl reverse phase HPLC column containing lipophilic and polar moieties was used.
RESULTS
The adsorption coefficient of the test item was determined to be > 4.27 x 10E05 with Log10 Koc > 5.63.
Reference
TABLE 3 – RETENTION TIMES, CAPACITY FACTOR AND LOG10 Koc VALUES FOR THE SAMPLE
Injection |
Retention time (min) |
Capacity factor (k’) |
Log10 k’ |
Log10 Koc |
1 |
≥ 43.826 |
> 12.6 |
> 1.1 |
> 5.63 |
2 |
≥ 43.828 |
> 12.6 |
> 1.1 |
> 5.63 |
Overall Log10 Koc range: > 5.63
Mean Log10 Koc: > 5.63
Adsorption coefficient range: > 4.27 x 10E05
Description of key information
The adsorption coefficient of the test item was determined to be > 4.27 x 10E05 with Log10 Koc > 5.63 (OECD 121 and EU Method C.19).
Key value for chemical safety assessment
Additional information
GUIDELINE
The determination was carried out using the HPLC screening method, designed to be compatible with Method C.19 Adsorption Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 121 of the OECD Guidelines for Testing of Chemicals, 22 January 2001. The test utilised a High Performance Liquid Chromatograph. A commercially available cyanopropyl reverse phase HPLC column containing lipophilic and polar moieties was used.
RESULTS
The adsorption coefficient of the test item was determined to be > 4.27 x 10E05 with Log10 Koc > 5.63.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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