Registration Dossier
Registration Dossier
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EC number: 210-039-7 | CAS number: 603-41-8
Adsorption / desorption
Administrative data
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 04-04-2006 to 06-04-2006
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted under GLP conditions in accordance with the official OECD guideline No 121 (2001).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Version / remarks:
- (January 2001)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Version / remarks:
- (August 2001)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- soil/sewage sludge
Test material
- Reference substance name:
- p,p'-(2-pyridylmethylene)bisphenol
- EC Number:
- 210-039-7
- EC Name:
- p,p'-(2-pyridylmethylene)bisphenol
- Cas Number:
- 603-41-8
- Molecular formula:
- C18H15NO2
- IUPAC Name:
- 4-[(4-hydroxyphenyl)(pyridin-2-yl)methyl]phenol
- Test material form:
- solid
1
- Radiolabelling:
- no
Study design
- Test temperature:
- 20 to 25°C
HPLC method
- Details on study design: HPLC method:
- EQUIPMENT- Apparatus: Balance: Mettler XP205DR; pH meter: Metrohm 692 with Metrohm electrode 6.0258.000; HPLC equipment: Varian autosampler ProStar 410, Varian pump ProStar 230, Varian UV/VIS detector 310, Jones column oven 7990- Type: Varian autosampler ProStar 410; Varian pump ProStar 230 - Type, material and dimension of analytical (guard) column: Jones column oven 7990; column: LiChrospher 100 CN, particle size 5 µm, 250 mm*4mm; pre-column: CN- Detection system: Varian UV/VIS detector 310; Test item: 274 nm; Reference item: 210 nm; Sodium nitrate: 210MOBILE PHASES- Type: methanol/water (55:45; v/v) - pH: adjusted to pH 7.0 (using sodium hydroxide)- Solutes for dissolving test and reference substances: LA 96 was dissolved in a solvent mixture of methanol and water (55:45 v/v); the stock solutions of the reference items were dissolved in methanol.DETERMINATION OF DEAD TIME- Method: The dead time to was mesured by using an unretained compound (sodium nitrate) which was included in the mix of the reference items.REFERENCE SUBSTANCES- Identity: Acetanilide; Isoproturon; Linuron; Pyrazophos; Diclofop-methyl; 2,4-DDTREPETITIONS- Number of determinations: 3EVALUATION- Calculation of capacity factors k': k' = (tr - t0) / t0t0 = retention timestr = dead time- Determination of the log Koc value: the log k' values were plotted against the log Koc of the reference items using linear regression yielding the following equation: slope = 0.155; y-axis intercept = 0.025; coefficient of regression (r) = 0.999
Results and discussion
Adsorption coefficientopen allclose all
- Type:
- log Koc
- Value:
- 1.9
- Temp.:
- 25 °C
- Type:
- Koc
- Value:
- 88
Any other information on results incl. tables
Table 1: Retention times in minutes of the reference items and the test items:
| 1st run | 2nd run | 3rd run | 4th run | 5th run | 6th run |
Sodium nitrate | 1.177 | 1.177 |
|
|
|
|
Reference Items: | ||||||
Acetanilide | 3.058 | 3.069 | 3.060 | 3.071 | 3.060 | 3.059 |
Isoproturon | 3.587 | 3.600 | 3.592 | 3.603 | 3.596 | 3.589 |
Linuron | 4.465 | 4.483 | 4.479 | 4.489 | 4.486 | 4.470 |
Pyrazophos | 5.698 | 5.729 | 5.730 | 5.737 | 5.747 | 5.707 |
Diclofop-methyl | 6.666 | 6.707 | 6.705 | 6.717 | 6.736 | 6.678 |
2,4-DDT | 10.252 | 10.360 | 10.343 | 10.385 | 10.429 | 10.293 |
LA 96 | ||||||
Test Item Peak | 3.656 | 3.657 | 3.695 |
|
|
|
Table 2: Result of LA 96 analyses:
Number of analyses | Retention time [min] | k‘ | Log k‘ | Log Koc | Mean log Koc | Koc | Mean Koc |
Test Item Peak |
|
|
|
|
|
|
|
1 | 3.66 | 2.11 | 0.3235 | 1.9 |
| 85.158 |
|
2 | 3.66 | 2.11 | 0.32368 | 1.9 |
| 85.381 |
|
3 | 3.70 | 2.14 | 0.33028 | 2.0 | 1.9 | 94.94.209 | 88.2 |
Applicant's summary and conclusion
- Conclusions:
- In conclusion, the log of the adsorption coefficient (Koc) of LA 96 was estimated to be log Koc = 1.9 which is equal to Koc value of 88 using the HPLC method. This value indicates that LA 96 is of high mobility.
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