Registration Dossier
Registration Dossier
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EC number: 248-697-2 | CAS number: 27858-32-8
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Testing is not scientifically justified as this substance is hydrolytically unstable and the decomposition products have a low potential for aquatic bioaccumulation and a low potential to cross biological membranes. The lowest acute toxicity (48-h LC50) of the decomposition product (EAA) is used as a key value.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 275 mg/L
Additional information
When this substance comes in contact with water or moisture, a complete hydrolysis will take place with no significant reaction products other than isopropyl alcohol (IPA), ethyl acetoacetate (EAA) and hydrated titanium dioxide (key study on hydrolysis Brekelmans 2013). The organic decomposition products are readily biodegradable having also low log Kow values (0.05; IPA and 0.25; EAA).
The CSA indicates that toxicity of this substance is similar to the main degradation products. Key studies (short-term toxicity to daphnia and algae) conducted for this substance justify that this substance hydrolyses during toxicity testing and the aquatic toxicity is similar to the isopropyl alcohol and ethyl acetoacetate released in water. Therefore, and for reasons of animal welfare, a short-term toxicity study on fish is unjustified, and the key value for CSA is obtained from the lowest 96-h LC50 of the degradation products. The only reliable study with fish was conducted for ethyl acetoacetate over 48-h period with Leuciscus idus (LC50 275 -575 mg/l; European Chemicals Bureau 2002). The lowest 96-h LC50 value of isopropyl alcohol with Rasbora heteromorpha is 4200 mg/l (peer-reviewed secondary source Tooby & Hursey 1975). The toxicity results of the degradation products do not trigger environmental hazard classification.
Despite the fact that the incubation time in the study conducted for ethyl acetoacetate is shorter than in the guideline OECD 203, the lowest toxicity value of the main degradation products (LC50 of ethyl acetoacetate) is selected for CSA.
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