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EC number: 249-576-7 | CAS number: 29340-81-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- See read-across record in section 13.
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 82
- Sampling time:
- 28 d
- Remarks on result:
- other:
- Remarks:
- Result from read-across source substance Cas No. 30798-32-4
- Key result
- Parameter:
- % degradation (test mat. analysis)
- Value:
- ca. 100
- Sampling time:
- 5 d
- Remarks on result:
- other: Primary biodegradation of 5.7 mg/l TEA in a test with 164 mg/l municipal activated sludge
- Remarks:
- Result from read-across source substance CAS No. 102-71-6
- Parameter:
- % degradation (test mat. analysis)
- Value:
- ca. 100
- Sampling time:
- 1 d
- Remarks on result:
- other: Primary biodegradation of 0.6 mg/l TEA in a test with 164 mg/l municipal activated sludge
- Remarks:
- Result from read-across source substance CAS No. 102-71-6
Reference
Description of key information
The test substance is readily biodegradable (according to OECD criteria)
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
- Type of water:
- freshwater
Additional information
No substance-specific data on the biodegradability of the substance (CAS 29340-81-6) are available. However, according to Article 13 of legislation EC1907/2006, in case no appropriate animal studies are available for assessment, information should be generated whenever possible by means other than vertebrate animal tests, i. e. applying alternative methods such as in vitro tests, QSARs, grouping and read-across. CAS 29340-81-6 is an organic compound manufactured from triethanolamine (TEA, CAS 102-71-6) and citric acid (CAS 77-92-9) and dissociates into the respective TEA cation and citrate anion. Therefore it is considered to be acceptable to derive lacking information on toxicological properties of CAS 29340-81-6 by read-across from its starting materials.
For TEA, the biodegradation potential in water was determined in a CO2 evolution test (no guideline given) (West, 1996). In this study 0.6 and 5.7 mg/L test substance was inoculated with mixed liquor activated sludge (secondary effluent) for 6 days under aerobic conditions. After the 6-day incubation period the substance was biodegraded c.a. 100% as CO2 evolution for both concentrations. Based on these findings, it is concluded that the TEA is readily biodegradable.
For MIPA citrate, the biodegradation potential of the substance in water was determined in a screening study according to OECD TG 301B (CO-Evolution Test) and in compliance with GLP criteria (Charles River, 2017). In this study, 41.5 mg/L test item (corresponding to 12 mg TOC/L) was inoculated with activated sludge from predominantly domestic sewage for 28 days under aerobic conditions in the dark. During the incubation period degradation was followed by determining the carbon dioxide produced. In addition, biodegradation of the reference substance sodium acetate (positive control) and inhibitory effects (toxicity control) were determined. Biodegradation of the reference substance was 85% after 14 days. Biodegradation degree of the toxicity control was 80% after 14 days. After the 28-day incubation period 82% of the test substance was biodegraded. The pass level of 60% degradation was reached within 11 days after the start of the test. Further calculation with mean values of biodegradation indicate the 10-day window was met. Based on these findings, the test substance is classified as readily biodegradable.
Taken together, it can be concluded that both starting products are readily biodegradable. Therefore, the test substance CAS 29340-81-6 is assessed to be readily biodegradable.
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