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Administrative data

Link to relevant study record(s)

Description of key information

No experimental toxicokinetic study is available on 3-methyl-1,5-pentanediyl diacrylate. However, as per REACH guidance document R7.C (May 2008), information on absorption, distribution, metabolism and excretion may be deduced from the physicochemical properties.
Based on the toxicological data and the physicochemical properties, the absorption of 3-methyl-1,5-pentanediyl diacrylate is expected to be low by oral route, dermal route and inhalation.

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential
Absorption rate - oral (%):
100
Absorption rate - dermal (%):
10
Absorption rate - inhalation (%):
100

Additional information

No experimental toxicokinetic study is available on 3-methyl-1,5-pentanediyl diacrylate. However, as per REACH guidance document R7.C (2012), information on absorption, distribution, metabolism and excretion may be deduced from the physical-chemical properties, including:

-Mean molecular weight: 226 g/mol

-Water solubility: 541 mg/L (20°C) (moderately soluble)

-Partition coefficient Log Kow: 2,76

-Vapour pressure: 0,105 Pa (20°C)

 

ABSORPTION

The moderate value of log Kow (between -1 and 4) and the moderate solubility of 3-methyl-1,5-pentanediyl diacrylate are favorable for an oral absorption. Indeed clinical effects as hunched posture were observed one or two days after one single (2000 mg/kg) of 3-methyl-1,5-pentanediyl diacrylate by gavage (oral route) in rats.

An oral absorption is expected for 3-methyl-1,5-pentanediyl diacrylate.

 

With a solubility of 541 mg/L, dermal absorption is anticipated to be moderate to high. A Log Kow of 2,76 and a molecular weight lower than 500 g/mol are optimal for a dermal absorption. Howerver, the acrylates are known to bind to skin components, and this binding decreases their dermal absorption. Indeed, the dermal absorption of 3-methyl-1,5-pentanediyl diacrylate is anticipated to be low.

According to the IH skin perm (QSAR), the dermal absorption of 3-methyl-1.5-pentanediyl diacrylate is 0.1%.

The low dermal absorption can be confirmed in the dermal acute toxicity study, where no systemic effect or mortality were observed in rats treated with 2000 mg/kg bw. However, 3-methyl-1,5-pentanediyl diacrylate showed allergic reaction in the LLNA: it is evidence that some uptake must have occurred although it may only have been a small fraction of the applied dose. For the risk assessment, 10% of dermal absorption is taken into account.

 

Based on the low value of the vapour pressure (<1 Pa), 3-methyl-1,5-pentanediyl diacrylate is not a volatile substance. Moreover, the absorption by inhalation can be expected for 3-methyl-1,5-pentanediyl diacrylate based on the moderate values of water solubility and log kow. The absorption is confirmed by the acute inhalation study in which mortalities were observed at the dose of 5.14 mg/L.

 

DISTRIBUTION and METABOLISM

No specific data is available on the distribution or metabolism of 3-methyl-1,5-pentanediyl diacrylate. No organ toxicity was showed in the repeated studies.

 

ELIMINATION

Due to the moderate water solubility and the low molecular mass (226 g/mol), the excretion of 3-methyl-1,5-pentanediyl diacrylate in the urines is expected. An excretion via bile and faeces is also possible.