Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 285-377-1 | CAS number: 85085-48-9 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Melaleuca alternifolia, Myrtaceae.
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
A review of the pharmacokinetics of tea tree oil has been conducted by an independent expert, a copy of which is included in IUCLID section 13. The text of the review has been reproduced in full in section 5.1 of the Chemical Safety Report.
Reference: Bartholomaeus, A. (2017) Tea Tree Oil Oral Dose
Selection for a Rat in vivo Toxicity Study. Pharmacokinetic
Considerations for Extrapolation from Oral to Dermal Exposures.
BartCrofts Scientific Services Pty Ltd. (Unpublished)
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 70
- Absorption rate - dermal (%):
- 3
- Absorption rate - inhalation (%):
- 100
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
