Registration Dossier
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EC number: 904-908-6 | CAS number: -
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- July 12th, 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- effusion method: Knudsen cell
- Key result
- Test no.:
- #1
- Temp.:
- 20 °C
- Vapour pressure:
- 0.078 Pa
- Key result
- Test no.:
- #2
- Temp.:
- 25 °C
- Vapour pressure:
- 0.157 Pa
- Conclusions:
- The test item has a vapour pressure of 0.0778 Pa at 20 ºC and 0.157 Pa at 25 ºC.
- Executive summary:
A study was performed to determine the vapour pressure of the test item according to OECD Guideline 104 "Vapour Pressure" and EEC A.4, under GLP conditions. The Effusion method (Knudsen cell) was used, estimating the test substance mass flowing out the Knudsen cell per unit of time, through a micro-orifice under ultra-vacuum conditions. The vapour pressure was then calculated by applying the Hertz-Knudsen relation with Clausing correction factor f that depends on the parameters of the apparatus: on the ratio of orifice length to orifice radius. The vapour pressure of the test item was determined to be 0.0778 Pa at 20 ºC and 0.157 Pa at 25 ºC.
Reference
Vapour pressure of Reaction mass of isopentyl salicylate and 2 -methylbutyl salicylate at 20 ºC and 25 ºC was calculates on the basis of equation:
log (p) = f /1/t) = a-b/(t+273.15)
Where:
p: vapour pressure in Pa
t: temperature in ºC
Obtained for three measurement points: 38.0ºC, 42.2ºC and 46.5ºC.
Description of key information
Key study. OECD Guideline 104 and EEC A.4. GLP study. The vapour pressure of the test item was determined to be 0.0778 Pa at 20ºC and 0.157 Pa at 25ºC.
Key value for chemical safety assessment
- Vapour pressure:
- 0.078 Pa
- at the temperature of:
- 20 °C
Additional information
Key study: The vapour pressure of the test item was determined according to OECD 104 and EU method A.4, under GLP conditions, using an apparatus with Knudsen cell. The determined vapour pressure of the test item was 0.0778 Pa at 20ºC and 0.157 Pa at 25ºC.
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