Registration Dossier
Registration Dossier
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EC number: 679-514-8 | CAS number: 154279-60-4
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Dose descriptor:
- NOAEL
- 10 mg/kg bw/day
Additional information
In a study by F.M. van Otterdijk et al. (2011) MTDID 25575 (trade name Clearlink 1000) potential reproduction and developmental toxicity have been evaluated in a screening test according to OECD Guideline 422. The test substance was administered by daily oral gavage to male and female Wista han rats at dose levels 1, 3 and 10 mg/kg/day. Males were exposed for 2 weeks prior to mating, during mating and up to termination (for 29 days). The females were exposed prior to mating, during mating, during post-coitum, and at least 4 days of lactation (for 42 -45 days). According the test results there were no indications of reproduction toxicity at the highest tested dose level (10 mg/kg/day).
Short description of key information:
MTDID 25575 (trade name Clearlink 1000) did not have effects on fertility at the highest tested dose level (10 mg/kg bw/day).
Effects on developmental toxicity
Description of key information
No developmental toxicity of MTDID 25575 (trade name Clearlink 1000) was observed at the highest dose level tested (10 mg/kg bw/day).
Effect on developmental toxicity: via oral route
- Dose descriptor:
- NOAEL
- 10 mg/kg bw/day
Additional information
In a study by F.M. van Otterdijk et al. (2011) MTDID 25575 (trade name Clearlink 1000) potential reproduction and developmental toxicity have been evaluated in a screening test according to OECD Guideline 422. The test substance was administered by daily oral gavege to male and femle Wista han rats at dose levels 1, 3 and 10 mg/kg/day. Males were exposed for 2 weeks prior to mating, during mating and up to termination (for 29 days). The females were lexposed prior to mating, during mating, during post-coitum, and at least 4 days of lactation (for 42 -45 days). According the test results there were no indications of developmental toxicity at the highest tested dose level (10 mg/kg/day).
Justification for classification or non-classification
No reproduction or developmental toxicity was observed at the highest tested dose level (10 mg/kg bw/day) and therefore no classification required.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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