Registration Dossier
Registration Dossier
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EC number: 807-821-0 | CAS number: -
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 24 to 27 June 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Data have been generated according to current internationally recognised study guidelines and in accordance with GLP.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- Instrument: High performance Liquid Chromatography, LC2010 AHT (Shimadzu) equipped with UV Vis detectorColumn: L-column2 ODS (150mm x 2.1mm I.D., particle size 5 µm)Temperature: 40CEluent: A (23%) Methanol, B (77%) 5 mmol/L ammonium acetate solutionFlow rate: 0.2mL/ minWavelength: 300 nmInjection volume: 1µL
- Vehicle:
- no
- Test organisms (species):
- Daphnia magna
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Hardness:
- 39 mg/L
- Test temperature:
- 20.2 - 20.6C
- pH:
- 7.7 - 7.9
- Dissolved oxygen:
- 8.8-8.9 mg/L
- Nominal and measured concentrations:
- 100 mg/L
- Reference substance (positive control):
- no
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Validity criteria fulfilled:
- yes
- Conclusions:
- The substance caused no immobilisation of Daphnia magna in te test system. The EC50 is >100mg/l
- Executive summary:
The acute immobilisation to Daphnia(Daphnia magna) has been assessed according to the OECD 202 test guideline in accordance with GLP with analytical monitoring at the start and end of exposure by HPLC. The analysis demonstrated that the concentration was consistent during the exposure period. Exposure resulted in no immobilisation. The EC50 was determined to be >100 mg/l.
Reference
Description of key information
The acute immobilisation to Daphnia (Daphnia magna) has been assessed according to the OECD 202 test guideline in accordance with GLP with analytical monitoring at the start and end of exposure by HPLC. The analysis demonstrated that the concentration was consistent during the exposure period. Exposure resulted in no immobilisation. The EC50 was determined to be >100 mg/l.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 100 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
