Registration Dossier
Registration Dossier
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EC number: 807-821-0 | CAS number: -
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 6-26 February 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Data have been generated according to current internationally recognised study guidelines and in accordance with GLP.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- soil/sewage sludge
- Radiolabelling:
- no
- Details on study design: HPLC method:
- Stationary Phase (HPLC Column): ACE 5 CN 150 × 4.6 mm, HPLC Column, No.: A47728 Merck-Hitachi LaChrom HPLC system: D-7000 Interface, No.: 1126-175 L-7100 HPLC pump, No.: 1388-056L-7200 Autosampler, No.: 1380-033 L-7400 UV Detector, No.: 1374-025 L-7360 Column Oven, No: 00118060 L-7614 Degasser, No.: 144116A0094 Ultrasonic bath: Elmasonic S300H, ELMA, No.: 010890105 Balances: BP221S Sartorius, No.: 11809117, Sartorius L220P, No.: 38100037 pH meter: Mettler Toledo, SevenEasy S20, No.: 1231025119 Water purification system: MILLIPORE, DIRECT Q8 UV, F3SA78247A Spectrophotometer: Hitachi U-2910, No.: 2221-004HPLC Conditions: Detector: UV at 254 nm Mobil Phase: 10 mM NaH2PO4 buffer solution (pH=6.0)/Acetonitrile=8/2 Flow: 1 ml/min. Injection volume: 20 μl Temperature: 25 °CDetermination of the retention times: Three series of the above reference solutions and the test item solution were measured alternately, with two replicate injections. For the determination of t0 (t0 = retention time of the unretarded component) sodium nitrate solution was injected. The retention times were determined.
- Type:
- log Koc
- Value:
- <= 1.25
- Temp.:
- 25 °C
- Type:
- Koc
- Value:
- <= 17.78
- Temp.:
- 25 °C
- Validity criteria fulfilled:
- yes
- Conclusions:
- The log Koc is <1.25
- Executive summary:
The adsorption coefficient was measured by the HPLC method in accordance with the OECD 121 test guideline in compliance with GLP. The log Koc is <1.25.
Reference
Due to the fact that BK-659 eluted before t0, the log Koc and Koc of BK-659 is lower than log Koc and Koc of the first reference substance (Acetanilide)
Description of key information
The adsorption coefficient was measured by the HPLC method in accordance with the OECD 121 test guideline in compliance with GLP. The log Koc is <1.25.
Key value for chemical safety assessment
- Koc at 20 °C:
- 17.78
Additional information
[LogKoc: 1.25]
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