Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 231-306-4 | CAS number: 7491-02-3
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Range-finding toxicity data: List IV
- Author:
- Smyth, H.F., Jr. et al.
- Year:
- 1 951
- Bibliographic source:
- Arch Ind Hyg Occup Med 4 (2): 119-122
- Reference Type:
- publication
- Title:
- The place of the range finding test in the industrial toxicology laboratory
- Author:
- Smyth, H.F., Jr. and Carpenter, C.P.
- Year:
- 1 944
- Bibliographic source:
- as cited in: Journal of industrial hygiene and toxicology 26 (8): 269-273
Materials and methods
- Principles of method if other than guideline:
- Rabbits are epidermally treated with the undiluted test substance for 4 days.
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- Dibutyl adipate
- EC Number:
- 203-350-4
- EC Name:
- Dibutyl adipate
- Cas Number:
- 105-99-7
- IUPAC Name:
- dibutyl adipate
- Details on test material:
- - Name of test material (as cited in study report): Dibutyl adipate
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- Undiluted test material was applied to the clipped skin of the rabbits trunk. The dose is retained under a flexible film of rubber, vinyl plastic or the like, selected to be impervious to the chemical.
- Duration of exposure:
- 4 days
- Doses:
- no data
(several dosages differing by a multiple of 10) - No. of animals per sex per dose:
- 6 animals (overall)
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
no further information available
Results and discussion
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 20 mL/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: LD50 was determined graphically.
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 19 220 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: calculated based on a density of 0.96 g/mL
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- CLP: not classified
DSD: not classified
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
