Registration Dossier

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1993

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method B.1 (Acute Toxicity (Oral))
GLP compliance:
yes
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-methylcyclohexanol, mixed isomers
EC Number:
209-512-0
EC Name:
2-methylcyclohexanol, mixed isomers
Cas Number:
583-59-5
Molecular formula:
C7H14O
IUPAC Name:
Reaction mass of trans-2-methylcyclohexanol and cis-2-methylcyclohexanol

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
polyethylene glycol
Doses:
200 mg/kg bw
633 mg/kg bw
2000 mg/kg bw
No. of animals per sex per dose:
5 animals per sex per dose
Control animals:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
1 125 mg/kg bw
Based on:
test mat.
Remarks:
geometric mean between 633 and 2000 mg/kg

Applicant's summary and conclusion