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Administrative data

Key value for chemical safety assessment

Additional information

Mutagenicity in vitro - bacterial systems:

The mutagenicity was tested in an Ames assay using the tester strains TA1535, TA1537, TA98, and TA100. The substance was tested in the following concentrations: 0.2, 2, 20, 200, 2000 µg per plate with and without a metabolic activation system (S9 -Mix of Aroclor 1254 induced rat liver). Under the given criteria for mutagenicity (doubling of spontaneous reversion rate and dose-response relationship), the test item was not mutagenic in the used test system. The study was performed equivalent to an outdated version of OECD TG 471 ( only 4 tester strains were used). The study is therefore considered to be valid with restrictions.


Short description of key information:
The substance is not mutagenic in an Ames assay using the tester strains TA1535, TA1537, TA98, and TA100, with and without metabolic activation (Ciba 1978).

Endpoint Conclusion:

Justification for classification or non-classification