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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 700-380-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Inhalation absorption
The potential for dust inhalation is considered to be of no relevance, since the substance at room temperature (20-25°C) is a liquid to waxy solid and not a powder with an inhalable size.Taking into account the vapour pressure of 3*10-5Pa at 25°C of SymMollient®S and the low water solubility(A: 3.5 µg/L/ B: 1.7 µg/L) inhalation of vapours can also be completely ruled out.
Oral absorption
SymMollient® S is of low water soluble (A: 3.5 µg/L/ B: 1.7 µg/L) and highly lipophilic (log Pow (calculated) = 11.2 / 12.2), therefore absorption may be limited by the lowability to dissolve in GI fluids and hence to be available in soluble form at the mucosal surface. However, the absorption will be enhanced if they undergo micellular solubilisation by bile salts.
Dermal absorption
SymMollient® S is intended to be used at a low application rate as a topical skin care product to regulate the moisture content of the skin by forming alight hydrophobic film on the skin that protects from drying out.
Based on the low water solubility (A: 3.5 µg/L/ B: 1.7 µg/L) and the high lipophilicity (logPow (calculated) = 11.2 / 12.2), quantitatively relevant dermal absorption cannot completely ruled out on the basis of theoretical considerations only.
Distribution
The substance is expected to reach the systemic circulation only to a very limited extend and in addition it is expected to be readily metabolised after passing the liver. Therefore, distribution SymMollient® S throughout the body is not very likely.
Metabolism and elimination
The carboxylesterase hydrolyses the carboxylic esters into a carboxylate and alcohol.
The alcohol will be oxidised in the liver to an aldehyde, catalysed by the alcohol/dehydrogenase containing the coenzyme NAD+. The aldehyde is further oxidised to the respective carboxylate. Both carboxylates will be broken down into acetyl-CoA-units, which will be metabolised in the citrate cycle just like the conventional metabolism of natural fatty acids, ultimately yielding carbon dioxide as respiration product.
In consequence, if small amounts of SymMollient® S reach the systemic circulation, the substance may be expected to be readily biotransformed to harmless, endogenous cellular constituents of the energy-producing metabolic pathway.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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