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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 203 (Fish, Acute Toxicity Test)
Principles of method if other than guideline:
Test conducted according to Internal Guideline A.11 Page 6
The acute fish toxicity testing was performed according to published methods, which were adapted and standardized for the specific needs of the company, well before Test Guidelines for these methods were established by the OECD beginning 1981. This method is comparable to today’s standard testing procedure published by the OECD within Guideline for Testing of Chemicals 203.
GLP compliance:
no
Remarks:
pre GLP
Analytical monitoring:
no
Vehicle:
no
Details on test solutions:
Water Solutions
Test organisms (species):
other: Trouts
Details on test organisms:
8 trouts per concentration
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
48 h
Test temperature:
16°C
pH:
after 48h:
(100 mg/l) pH = 8.1
(3, 30, 10 mg/l) pH = 8
Nominal and measured concentrations:
nominal concentrations: 3 mg/l, 10 mg/l, 30 mg/l, 100 mg/l
Reference substance (positive control):
no
Duration:
48 h
Dose descriptor:
LC0
Effect conc.:
ca. 3 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
ca. 14.5 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Duration:
48 h
Dose descriptor:
LC100
Effect conc.:
ca. 30 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Sublethal observations / clinical signs:

conc. survivors pH O2 Comments
24h 48h 48h 48h
100 mg/l 0 - 8.1
3 mg/l 8 8 8
30 mg/l 8 0 8
10 mg/l 8 6 8
Validity criteria fulfilled:
not specified
Conclusions:
LC50 = 14.5 mg/l
Executive summary:

The substance has been tested for acute fish toxicity according to Internal Method A.11. During the test 8 trouts of undefined specie have been used per concentration. The tested concentrations were 3, 10, 30, 100 mg/l in water. The test has shown TL0 = 3 mg/l, TL50 = 14.5 mg/l and TL100 = 30 mg/l.

Description of key information

LC50 Freshwater = 14.5 mg/l

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
14.5 mg/L

Additional information

According to the CLP Regulation (EC) n. 1272/2008 ‘acute (short-term) hazard’ means for classification purposes the hazard of a substance or mixture caused by its acute toxicity to an organism during short-term aquatic exposure to that substance or mixture.

For acute toxicity to fish one test is available with an LC50 = 14.5 mg/l. Moreover the substance shows a logPow= -0.4975 and no evidence of rapid biodegradation.

For acute fish toxicity the publication of Yung-Tse Hung (2013)[1](LD50 = 12 mg/l) is referred in the OECD Toolbox database.

[1]"Handbook of environment and waste management" Yung-Tse Hung, Lawrence K Wang, Nazih K.Shamannas