Registration Dossier
Registration Dossier
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EC number: 414-380-4 | CAS number: 140681-55-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Annex V
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- -
- EC Number:
- 414-380-4
- EC Name:
- -
- Cas Number:
- 140681-55-6
- Molecular formula:
- C7H14B2ClF9N2
- IUPAC Name:
- 1-(chloromethyl)-4-fluoro-1,4-diazabicyclo[2.2.2]octane-1,4-diium; bis(tetrafluoroboranuide)
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Test animals
- Species:
- other: Rat (Wistar albino)
Administration / exposure
- Route of administration:
- other: Distilled water
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 350 mg/kg bw
- Mortality:
- Male: 500 mg/kg bw; Number of animals: 5; Number of deaths: 0
Male: 600 mg/kg bw; Number of animals: 5; Number of deaths: 2
Male: 750 mg/kg bw; Number of animals: 5; Number of deaths: 4
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 5
Female: 250 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 350 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 500 mg/kg bw; Number of animals: 5; Number of deaths: 5
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 5 - Clinical signs:
- other: Signs of toxicity related to dose levels: 100% mortality was seen in females at 500 mg/kg and both sexes at 2000 mg/kg. All these deaths occurred on the day of dosing. Male deaths at 600 and 700 mg/kg occurred within 2-days post-dosing. Decedents at 2000
- Gross pathology:
- Effects on organs:
Discolouration and/or distension of the gastrointestinal
tract, liver and pancreas was seen in animals treated with
500 mg/kg and above. In addition, congestion of lungs was
seen in males at 750 mg/kg.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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