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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed
Year:
1994

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Annex V
GLP compliance:
yes
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
414-380-4
EC Name:
-
Cas Number:
140681-55-6
Molecular formula:
C7H14B2ClF9N2
IUPAC Name:
1-(chloromethyl)-4-fluoro-1,4-diazabicyclo[2.2.2]octane-1,4-diium; bis(tetrafluoroboranuide)
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder

Test animals

Species:
other: Rat (Wistar albino)

Administration / exposure

Route of administration:
other: Distilled water

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 350 mg/kg bw
Mortality:
Male: 500 mg/kg bw; Number of animals: 5; Number of deaths: 0
Male: 600 mg/kg bw; Number of animals: 5; Number of deaths: 2
Male: 750 mg/kg bw; Number of animals: 5; Number of deaths: 4
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 5
Female: 250 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 350 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 500 mg/kg bw; Number of animals: 5; Number of deaths: 5
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 5
Clinical signs:
other: Signs of toxicity related to dose levels: 100% mortality was seen in females at 500 mg/kg and both sexes at 2000 mg/kg. All these deaths occurred on the day of dosing. Male deaths at 600 and 700 mg/kg occurred within 2-days post-dosing. Decedents at 2000
Gross pathology:
Effects on organs:
Discolouration and/or distension of the gastrointestinal
tract, liver and pancreas was seen in animals treated with
500 mg/kg and above. In addition, congestion of lungs was
seen in males at 750 mg/kg.

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: EU