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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: study performed according to OECD and GLP guidelines
Cross-reference
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1997
Report date:
1997

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Deviations:
no
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
6,8-dimethylnona-3,5-dien-2-one
EC Number:
274-446-1
EC Name:
6,8-dimethylnona-3,5-dien-2-one
Cas Number:
70214-76-5
Molecular formula:
C11H18O
IUPAC Name:
6,8-dimethylnona-3,5-dien-2-one

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
semiocclusive
Preparation of test site:
clipped
Vehicle:
unchanged (no vehicle)
Controls:
no
Duration of treatment / exposure:
4 hours
Observation period:
14 days
Number of animals:
3 female

Results and discussion

In vivo

Results
Irritation parameter:
primary dermal irritation index (PDII)
Basis:
mean
Time point:
other: 72 h
Score:
ca. 3.7
Reversibility:
fully reversible within: 7 days
Other effects:
-

Any other information on results incl. tables

-

Applicant's summary and conclusion

Interpretation of results:
irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Dimethylnonadienon, is considered to be a moderate irritant when applied to the skin of the albino rabbit.
Executive summary:

The procedures used were in accordance with those described in OECD Guideline number 404 of 17th July 1992.

A 0.5 ml aliquot of the test article was applied over a previously clipped area of the dorsal skin of 3 albino rabbits. The test article was held in contact with the skin, under a semi-occlusive patch assembly, for a 4 hour period. At the end of this period, the patches were removed and the treated site on each animal gently cleansed with luke warm water. Skin reaction, i.e. erythema and eschar formation as well as oedema, was assessed one, 24, 48 and 72 hours after patch removal and 7 and 14 days after dosing. In the animal used for the preliminary screen, reaction to treatment was apparent within 1 hour of patch removal and was characterised by well defined to moderate erythema and slight to moderate oedema. At a subsequent examination, 7 days after dosing, there was a reduction in the intensity of erythema; oedema however, remained moderate. At the final examination 14 days after dosing, only a barely perceptible erythema was evident at the treated skin site of this animal. In the two remaining animals, slight to well defined erythema and slight oedema was apparent throughout the initial 72 hours. This irritation was no longer evident 7 days after dosing and no abnormalities were detected at the treated skin site of either animal.

The Primary Irritation Index was calculated to be 3.7