Registration Dossier
Registration Dossier
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EC number: 228-391-5 | CAS number: 6258-06-6
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Manufacturer / producer data without proof.
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1991
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
- GLP compliance:
- yes
- Type of assay:
- micronucleus assay
Test material
- Reference substance name:
- Sodium 1-amino-4-bromo-9,10-dioxoanthracene-2-sulphonate
- EC Number:
- 228-391-5
- EC Name:
- Sodium 1-amino-4-bromo-9,10-dioxoanthracene-2-sulphonate
- Cas Number:
- 6258-06-6
- Molecular formula:
- C14H8BrNO5S.Na
- IUPAC Name:
- sodium 1-amino-4-bromo-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- no data
- Duration of treatment / exposure:
- no data
- Frequency of treatment:
- once
- Post exposure period:
- no data
Doses / concentrations
- Remarks:
- Doses / Concentrations:
20, 175, 350, 700 mg/kg bw
Basis:
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Positive control(s):
- no data
Examinations
- Tissues and cell types examined:
- no data
Results and discussion
Test results
- Sex:
- not specified
- Genotoxicity:
- negative
- Remarks:
- No relevant indications of a clastogenic effect were found up to and including 700 mg/kg.
- Toxicity:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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