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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

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Administrative data

Link to relevant study record(s)

Description of key information

QSAR model, iSafeRat holistic approach v1.3, key study, validity 2:
72h-ErC50 = 14.64 mg/L (95% CL: 12.91 - 16.61 mg/L).

Key value for chemical safety assessment

EC50 for freshwater algae:
14.64 mg/L

Additional information

To assess the toxicity of the registered substance to aquatic algae, one data point is available.

This value (KREATiS, 2015), assessed as a key datapoint, is a QSAR. This QSAR prediction (iSafeRat holistic approach v1.3) was performed on the registered substance, to assess the inhibition of growth to algae of the substance. This QSAR has been validated to be compliant with the OECD recommendations for QSAR modelling (OECD, 2004) and predicts the endpoint value which would be expected when testing the substance under experimental conditions in a laboratory following OECD Guideline 201. The growth inhibition of algae was determined using a validated QSAR for the Mode of Action in question, (MOA 1, non-polar narcosis). This QSAR is based on validated data for a training set of 40 chemicals derived from 72-hour ErC50 tests on algae, for which the concentrations of the test substance had been determined by chemical analyses over the test period. The water solubility of the substance given as input was experimentally measured (380.4 mg/L). The substance falls within the applicability domain of the model. The 72 -h ErC50 based on growth rate was determined to be 14.64 mg/L (95%-Confidence Limit: 12.91 - 16.61 mg/L).

In conclusion, as the same QSAR model was validated for the "short-term toxicity to aquatic invertebrates" endpoint with an experimental study on an analogue substance and the results from this prediction were observed to be similar to those obtained from an experimental study, this result can be used with high reliability. Therefore, the 72h-ErC50 value was considered to be 14.64 mg/L (95% CL: 12.91 - 16.61 mg/L).