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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation
Remarks:
in vivo
Type of information:
calculation (if not (Q)SAR)
Remarks:
Migrated phrase: estimated by calculation
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
other: Authoritative data base
Title:
Danish QSAR study for CAS No.: 41687-30-3
Author:
Danish EPA Model
Year:
2012
Bibliographic source:
QSAR predictions by Danish Environmental Protection Agency (EPA)model powered by OASIS database:-Commercial

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: modelling database
Principles of method if other than guideline:
Data is from Sensitization (dermal). Multicase model.
GLP compliance:
no
Type of study:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2-[(3-nitrophenyl)sulphonyl]ethanol
EC Number:
255-501-9
EC Name:
2-[(3-nitrophenyl)sulphonyl]ethanol
Cas Number:
41687-30-3
Molecular formula:
C8H9NO5S
IUPAC Name:
3 Nitrophenyl-B-Hydroxyethylsulfone
Details on test material:
- Name of test material (as cited in study report): 2-[(3-nitrophenyl)sulphonyl]ethanol
- Substance type: Organic
- Physical state: Solid

In vivo test system

Test animals

Species:
other: no data
Strain:
not specified
Sex:
not specified

Study design: in vivo (non-LLNA)

Induction
Route:
other: no data
Vehicle:
no data
Challenge
Route:
other: no data
Vehicle:
no data

Results and discussion

In vivo (non-LLNA)

Results
Reading:
1st reading
Group:
test chemical
Dose level:
no data
Clinical observations:
Skin sensitization: Positive
Remarks on result:
other: Reading: 1st reading. Group: test group. Dose level: no data. Clinical observations: Skin sensitization: Positive.

Any other information on results incl. tables

Skin sensatization - positive have been indicated

Applicant's summary and conclusion

Interpretation of results:
not sensitising
Remarks:
Migrated information Criteria used for interpretation of results: EU
Executive summary:

According to Danish QSAR using multicase model estimated that 2-[(3-nitrophenyl)sulphonyl]ethanol is sensatising to skin. But the

experimental study of the read across substance indicated that the substance will be not irritating to the animals, so we can consider the target substance to be a mild irritant. Since the positive value is a predicted value so the same compeltely cannot be used for classification when a structually analog subtance indicates that the same is not classified. Thus, it has been categories in the mild irritant category but cannot be considered for the classification as per the EU regulation of C&L (as a category of mild irritation does not exist in the regulation).

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