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EC number: 275-108-6 | CAS number: 71002-20-5
Particle size distribution (Granulometry)
Administrative data
Link to relevant study record(s)
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From the 17th to the 20th of September, 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was performed according to SOP STR 071 analytical method.Test conducted according to internationally accepted testing guidelines.
- Qualifier:
- according to guideline
- Guideline:
- other: SOP STR 071
- Principles of method if other than guideline:
- The analysis was performed with and without 1 and 2 minutes of ultrasonics.
- GLP compliance:
- no
- Type of method:
- Laser scattering/diffraction
- Type of distribution:
- volumetric distribution
- Percentile:
- D50
- Remarks on result:
- other: Migrated from fields under 'Mass median diameter' as D50 percentile. No source field for Standard deviation.
- Percentile:
- D10
- Mean:
- 28.806 µm
- Remarks on result:
- other: after 1 minute of ultrasonic treatment
- Percentile:
- D50
- Mean:
- 71.206 µm
- Remarks on result:
- other: after 1 minute of ultrasonic treatment
- Percentile:
- D10
- Mean:
- 23.36 µm
- Remarks on result:
- other: after 2 minutes of ultrasonic treatment
- Percentile:
- D50
- Mean:
- 60.256 µm
- Remarks on result:
- other: after 2 minutes of ultrasonic treatment
- Conclusions:
- Particle size after 1 minute of ultrasonic treatmentD10 ca. 30.2 µmD50 > 69.183 < 79.433 µm (mean value 71.206 µm)D90 > 120.226 < 138.038 µmParticle size after 2 minutes of ultrasonic treatment D10 > 22.900 < 26.303 µm D50 > 60.256 < 69.183 µm (mean value 60.501 µm) D90 > 104.713 < 120.226 µm
- Executive summary:
Granulometry of the sample was performed with SOP-STR 071 method without and with 1 and 2 minutes of ultrasonic treatment.
Particle size after 1 minute of ultrasonic treatment
D10 ca. 30.2 µm
D50 > 69.183 < 79.433 µm (mean value 71.206 µm)
D90 > 120.226 < 138.038 µm
Particle size after 2 minutes of ultrasonic treatment
D10 > 22.900 < 26.303 µm
D50 > 60.256 < 69.183 µm (mean value 60.501 µm)
D90 > 104.713 < 120.226 µm
Reference
After 1 minute of ultrasonic treatment:
Specific Weighted mean D (3,2): 49.995 µm
Vol. Weighed mean D (4,3): 75.843 µm
After 2 minutes of ultrasonic treatment:
Specific Weighted mean D (3,2): 42.162 µm
Vol. Weighed mean D (4,3): 65.169 µm
See graph for details.
Description of key information
D50 mean 71.206 µm (1 minute of ultrasonics)
D50 mean 60.501 µm (2 minute of ultrasonics)
Additional information
Granulometry of the sample was performed with SOP-STR 071 method without and with 1 and 2 minutes of ultrasonic treatment.
Particle size after 1 minute of ultrasonic treatment
D10 ca. 30.2 µm
D50 > 69.183 < 79.433 µm (mean value 71.206 µm)
D90 > 120.226 < 138.038 µm
Particle size after 2 minutes of ultrasonic treatment
D10 > 22.900 < 26.303 µm
D50 > 60.256 < 69.183 µm (mean value 60.501 µm)
D90 > 104.713 < 120.226 µm
Granulometry is of considerable importance for the toxic properties of a substance as it influences aspects such as the route of exposure of humans and toxicity by inhalation: the choice of route of administration for animal testing, the efficiency of uptake in an organism and the distribution in the environment.
For this purpose fractions can be divided in:
• Inhalable fraction (the mass fraction of particles that can be inhaled by nose and mouth. Particles > 100 μm are not included in the inhalable convention;
• Thoracic fraction (the mass fraction of the inhaled particles that passes the larynx). The convention for thoracic fraction sets that 50 % of the particles in air with an aerodynamic diameter of 10 μm belong to the thoracic fraction;
• Respirable fraction (the mass fraction of the inhaled particles that reaches the alveoli) The convention for respirable fraction sets that 50 % of particles with an aerodynamic diameter of 4 μm belong to the respirable fraction.
The substance to be registered presented a granulometry (D50 after 2 minutes of ultrasonic treatment) that can be considered as an inhalable fraction.
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