Chlorosulphuric acid

Long-term toxicity to fish

Link to relevant study record(s)

Reference

Endpoint:

long-term toxicity to fish, other

Type of information:

calculation (if not (Q)SAR)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

accepted calculation method

Justification for type of information:

Data is from computational model developed by USEPA

Qualifier:

according to guideline

Guideline:

other: Modelling database

Principles of method if other than guideline:

Long term toxicity to fish was carried out according to the EPISUITE, ECOSAR.

GLP compliance:

no

Analytical monitoring:

no

Vehicle:

no

Test organisms (species):

other: Fish

Test type:

semi-static

Water media type:

freshwater

Total exposure duration:

28 d

Reference substance (positive control):

not specified

Key result

Duration:

28 d

Dose descriptor:

NOEC

Effect conc.:

473.6 mg/L

Nominal / measured:

estimated

Conc. based on:

test mat.

Basis for effect:

mortality

Remarks on result:

other: Neutral Organics SAR (Baseline toxicity)

Validity criteria fulfilled:

not specified

Conclusions:

On the basis of no effects observed in a semi-static freshwater system, the NOEC value for the substance is estimated to be 473.6 mg/l for fish for 28 days of exposure duration

Executive summary:

Based on the prediction done using ECOSAR class, the long term toxicity on fish was predicted for test substance. On the basis of no effects observed in a semi-static freshwater system, the NOEC value for the substance is estimated to be 473.6 mg/l for fish for 28 days of exposure duration. Based on this value, it can be concluded that the test chemical can be considered as nontoxic to fish at environmentally relevant concentration and can be considered to be not classified as per the CLP classification criteria. 

Description of key information

Based on the prediction done using ECOSAR class, the long term toxicity on fish was predicted for test substance. On the basis of no effects observed in a semi-static freshwater system, the NOEC value for the substance is estimated to be 473.6 mg/l for fish for 28 days of exposure duration. Based on this value, it can be concluded that the test chemical can be considered as nontoxic to fish at environmentally relevant concentration and can be considered to be not classified as per the CLP classification criteria. 

Key value for chemical safety assessment

Fresh water fish

Fresh water fish

Effect concentration:

473.6 mg/L

Additional information

Based on the various long term studies available for the test chemical, studies were reviewed to determine the toxic nature of test chemical on the mortality of fish. The studies are as mentioned below:

Based on the prediction done using ECOSAR class, the long term toxicity on fish was predicted for test substance. On the basis of no effects observed in a semi-static freshwater system, the NOEC value for the substance is estimated to be 473.6 mg/l for fish for 28 days of exposure duration. Based on this value, it can be concluded that the test chemical can be considered as nontoxic to fish at environmentally relevant concentration and can be considered to be not classified as per the CLP classification criteria. 

Above data is supported by the second study. Long term toxic effect of test chemical were done with Tribolodon hakonensis for 10 days. Test conducted under the static system for 10 days. After the exposure of test chemical with fish Tribolodon hakonensis (Japanese barbel) for 10 days, LC50 was observed at 630 mg/l. Based on the LC50, chemical consider to be nontoxic and not classified as per the CLP classification criteria.

Thus based on the above data and experimental reports, chemical consider to be nontoxic and not classified as per the CLP classification criteria.