Registration Dossier
Registration Dossier
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EC number: 201-077-5 | CAS number: 78-04-6
Partition coefficient
Administrative data
Link to relevant study record(s)
Description of key information
In accordance with Annex XI section 2 of the Regulation EC 1907/2006, testing for a specific endpoint may be omitted, if it is technically not possible to conduct the study as a consequence of the properties of the substance.
The following statement was included in a physico-chemical properties study by Walker & White (2010) concerning the feasibility of a partition coefficient study on the test substance:
"No determination was possible according to Methods 107 and/or 117 of the OECD Guidelines for Testing of Chemicals, 27 July 1995 and 13 April 2004, respectively, and Method A8 Partition Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008, due to the following reason:
• During method development, it was noted that the test item is insoluble in n-octanol, water and typical reverse phase HPLC solvents."
Key value for chemical safety assessment
Additional information
Value used for CSA:1.27 ± 0.017 (calculated)
The study was considered to be not technically feasible according to the information provided in the Walker & White, 2010 study due to the test item being insoluble in n-octanol, water and typical reverse phase HPLC solvents.
The following supporting studies are also available:
- In the Tsuda et al, 1986 paper, the Log Pow was calculated to be 1.27 ± 0.017.
A reliability rating of 4 was assigned, according to the criteria of Klimisch, 1997 as in the study there are interferences between the measuring system and the test substance or in which organsisms/test systems were used which were not relevant to the exposure or which were performed according to a method which is not acceptable, the documentation of which is not sufficient for an assessment to be made and which is not convincing for expert judgement.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
