Registration Dossier

Administrative data

Description of key information

In a skin irritation study conducted to OECD 404 and GLP (Springborn Laboratories, 2000) Dequest 2066A (sodium salt of DTPMP) was very mildly irritating to the skin of rabbits. 
In an eye irritation study conducted to OECD 405 and GLP (Springborn Laboratories, 2000b) Dequest 2066A (sodium salt of DTPMP) was not irritating to the eyes of rabbits.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Additional information

The most reliable studies were selected as the key studies. The supporting studies also show the sodium salts of DTPMP are, at most, mildly irritating to the skin and eyes of rabbits.


Effects on skin irritation/corrosion: slightly irritating

Justification for classification or non-classification

The irritation potential of DTPMP salts is dependent on the ionisation state and affects classification as follows for skin irritation, where x .1 Cat 2 H-314, x = 2,9 NC; x=10 Cat 1 H-314. For eye irritation the same principle applies and the classification of the salts is based on the following; x ≤ Cat 1 H-318; x=2,9 NC; x=10 Cat 1 H-318.