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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Toxicity of antioxidants to tetrahymena pyriformis
Author:
Epstein SS, Saporoschetz IB, Hutner SH
Year:
1967
Bibliographic source:
J Protozool, Vol. 14 (2), 238-243

Materials and methods

Principles of method if other than guideline:
The cytotoxicity of 97 antioxidants of various structural types, among these the test substance, was determined for Tetrahymena pyriformnis grown in a peptone medium.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2,6-di-tert-butyl-4-(4,6-bis(octylthio)-1,3,5-triazin-2-ylamino)phenol
EC Number:
213-590-1
EC Name:
2,6-di-tert-butyl-4-(4,6-bis(octylthio)-1,3,5-triazin-2-ylamino)phenol
Cas Number:
991-84-4
Molecular formula:
C33H56N4OS2
IUPAC Name:
2,6-di-tert-butyl-4-(4,6-bis(octylthio)-1,3,5-triazin-2-ylamino)phenol

Results and discussion

Any other information on results incl. tables

The test substance had low toxicity to Tetrahymena pyriformis (median ID50: >1000 µg/ml) and low toxicity to rat (LD50: >5 g/kg bw) as well as high antioxidant activity by the photodynamic test when related to d-a-Tocopherol (value 3.1 for the test substance and 1 for tocopherol).

Applicant's summary and conclusion