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EC number: 235-911-4 | CAS number: 13040-19-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- September 1989
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: EEC guideline 84/449/EEC, 1984-09-19
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Zinc diricinoleate
- EC Number:
- 235-911-4
- EC Name:
- Zinc diricinoleate
- Cas Number:
- 13040-19-2
- Molecular formula:
- C18H34O3.1/2Zn
- IUPAC Name:
- zinc bis(12-hydroxyoctadec-9-enoate)
- Reference substance name:
- 9-Octadecenoic acid, 12-hydroxy-, zinc salt (2:1)
- IUPAC Name:
- 9-Octadecenoic acid, 12-hydroxy-, zinc salt (2:1)
- Reference substance name:
- zinc ricinoleate
- IUPAC Name:
- zinc ricinoleate
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source:Harald Schriever, Kaninchenfarm, D-2740 Bremervörde
- Weight at study initiation: 2.4 - 2.8 kg
- Housing: single caging
- Diet (e.g. ad libitum):Sniff, ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 7 d
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18 +-2
- Humidity (%): 50 - 85
- Air changes (per hr): -
- Photoperiod (hrs dark / hrs light): 12 / 12
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: left side shaved and abraded, right side shaved.
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.5 g; the test substance was applied undiluted
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 72 hours
- Number of animals:
- 6
- Details on study design:
- The test substance was applied on the right (intact) and left (scarified) back (size of areas each about 2.5 x 2.5 cm). At once the treated test areas and the untreated control areas underneath the test areas were secured with "Kosmoplast" and gauze pads. After that the whole trunk was wrapped with "Elastoplast" (permeable to air). Besides the trunk was wrapped with "Stülpa". This skin occlusive dressing was left on the skin for 4 hours. After that time the bandage was removed and residues of the sample were removed with gentle lukewarm water.
Results and discussion
In vivo
Results
- Irritation parameter:
- other: Individual scoring according to Draize scheme
- Basis:
- mean
- Time point:
- other: 24, 48, 72 h
- Score:
- 0
- Max. score:
- 24
- Irritant / corrosive response data:
- No erythema and no edema was observed on intact and on scarified skin areas.
- Other effects:
- No other effects were observed.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Grillocin PY 88 is not irritating to skin.
- Executive summary:
The test substance is a white solid powder and was tested regarding its acute skin irritation potential in 6 rabbits according to OECD Guideline 404 (Acute Dermal Irritation / Corrosion). Dermal reactions at the treated skin sites (scarified and intact) were assessed 4 hours and 24, 48, and 72 hours after application of the test substance. Skin reactions have not been observed, numerical scores for erythema and edema were “0” for all observations. Grillocin PY 88 is valuated as not irritant to skin.
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