Registration Dossier
Registration Dossier
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EC number: 235-747-3 | CAS number: 12650-88-3
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
Expected non-toxic to aquatic algae.
Key value for chemical safety assessment
Additional information
No specific information exists on the short-term toxicity to algae of lysozyme.
However considering that Lysozyme is naturally occurring in many organisms, including aquatic organisms, it is expected to be non-toxic for aquatic life.
In order to support this consideration below are reported the data available for Lipase, from the HERA documentation:
EC50 for inhibition of growth at 72-h = 97 mg active enzyme protein (aep)/L.
EC50 for inhibition of maximum growth rates at 24 and 72 h = 99 mg aep/L.
NOEL = 40 mg aep/L [1 -2]
Data on Lipase describe the enzyme to have very low toxicity and this supports the consideration that Lysozyme may be characterized as non-toxic to aquatic algae. Since data available are not specific for Lysozyme, it is preferred to make a qualitative assessment.
Reference
[1] HERA Human and environmental risk assessment on ingredients of household cleaning products - alpha-amylases, cellulases and lipases. 2005.
[2] Greenough RJ, Everett DJ (1991) Safety evaluation of alkaline cellulase. Food and Chemical Toxicology 29: 781-785.
[3] Oystein Lie, Oystein Evensen, Anita Sorensen, Ellen Froysadal. Study on lysozyme activity in some fish species. Dis. aquat. Org. 6: 1-5, 1989
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