Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-703-2 | CAS number: 109-77-3
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
Test item produced a 44% sensitisation rate (8/18).
Migrated from Short description of key information:
Study was performed according to OECD Guidelines for Testing of Chemicals No. 406 "Skin Sensitisation" - Magnusson & Kligman Maximisation Test,
method B6 in Annex V of EEC Directive 84/449/EEC. GLP study, reliable without restrictions (score 1).
Species: Albino Dunkin-Hartley guinea pig
Forty guinea pigs were used for the main study, twenty test and twenty control animals.
Concentration main study:
Intradermal Induction: 1% (w/v) in distilled water
Topical Induction : 5% (w/v) in distilled water
Topical Challenge : 2% (w/v) in distilled water
Incidence of sensitisation responses in test animals 8/18, 44% sensitisation response, moderate sensitiser
Respiratory sensitisation
Endpoint conclusion
- Additional information:
- Migrated from Short description of key information:
No information available.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
