1,2-dimethylimidazole

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Remarks:

Meets generally accepted scientific standards, well documented and acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1965

Report date:

1965

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Version / remarks:

prior to the adoption of OECD401 in 1981

Principles of method if other than guideline:

BASF-Test: The study was conducted according to an internal BASF method which in principle is comparable to the OECD Guideline 401.
A test group consisting of 5 animals/sex was treated by single gavage application with an aqueous solution of the test substance. The animals were observed for mortality and for clinical symptoms of toxicity. At the end of the observation period of 14 days, the surviving animals were sacrificed for the purpose of necropsy; animals that died during the observations period also were subjected to necropsy.

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

1,2-dimethylimidazole

EC Number:

217-101-2

EC Name:

1,2-dimethylimidazole

Cas Number:

1739-84-0

Molecular formula:

C5H8N2

IUPAC Name:

1,2-dimethyl-1H-imidazole

Details on test material:

- Name of test material (as cited in study report): 1,2-Dimethylimidazol
- Physical state: solid

Test animals

Species:

rat

Strain:

other: US-rats

Sex:

male/female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

water

Details on oral exposure:

VEHICLE
- Concentration in vehicle: 2% or 20% v/v

Doses:

200, 800, 1000, 1250, 1600 mg/kg bw

No. of animals per sex per dose:

5-10

Control animals:

no

Details on study design:

- Duration of observation period following administration: 7 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Statistics:

no data

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

ca. 1 300 mg/kg bw

Based on:

test mat.

Mortality:

0/10 animals died at 200 mg/kg bw
1/10 animals died at 800 mg/kg bw
2/10 animals died at 1000 mg/kg bw
4/10 animals died at 1250 mg/kg bw
14/20 animals died at 1600 mg/kg bw
deaths occured within day 1-2

Clinical signs:

other: On the day of administration: partly/slight staggering, shaking, slight dyspnoea, mild cramps, trembling. On the following days: apathy, rough coat, sometimes bloody crusted nose and eyes. The surviving aninmals were without findings within 1-6 days.

Gross pathology:

stomach filled with test substance and bleeding of gastric mucosa in the dead animals, organs of the surviving animals without findings