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EC number: 206-490-4 | CAS number: 349-76-8
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 31 Oct to 08 Nov 1996
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- GLP compliance:
- yes
- Remarks:
- Federal Department of the Interior and the Intercantonal Office for the Control of Medicaments, Switzerland
- Type of method:
- gas saturation method
- Temp.:
- 25 °C
- Vapour pressure:
- 35 Pa
- Conclusions:
- The test item has a vapour pressure of 35 Pa at 25 °C.
- Executive summary:
A study was conducted according to OECD Guideline for Testing of Chemicals, Vapour Pressure, No. 104 and
European Communities No. L 383 A, Method A.4. Vapour Pressure to assess the vapour pressure of the test substance.
The test substance was coated on glass beads which were filled in the thermostated saturator columns. Under well controlled flow and temperature conditions, a stream of nitrogen, preheated to the test temperature, was passed over the samples in the saturator columns. At the end of the saturator columns, the saturated gas stream was passed through two cooling traps in series where the test substance was condensed. The inlet of the first cooling trap was thermostated to the test temperature. At each test temperature, three determinations were made, each at a different flow rate to ensure saturation control. If the determined vapour pressures did not differ more than the estimated reproducibility of the method, the saturation of the gas stream was ensured.
After the collecting time, the cooling traps were removed. The transported test substance was dissolved in a solvent and the amount was quantitatively determined by HPLC with external standard calibration. From the amount of transported test substance, the test temperature and the volume of nitrogen, the vapour pressure was calculated according to the ideal gas law.
A vapour pressure of 35 Pa at 25 °C was determined for the test substance.
Reference
The vapour pressure of the reference substance anthracene measured directly at 25 °C with the test equipment was 1.17x10 Pa which is in good agreement with the literature reportings.
Description of key information
A study was conducted according to OECD Guideline for Testing of Chemicals, Vapour Pressure, No. 104 and
European Communities No. L 383 A, Method A.4. Vapour Pressure to assess the vapour pressure of the test substance.
The test substance was coated on glass beads which were filled in the thermostated saturator columns. Under well controlled flow and temperature conditions, a stream of nitrogen, preheated to the test temperature, was passed over the samples in the saturator columns. At the end of the saturator columns, the saturated gas stream was passed through two cooling traps in series where the test substance was condensed. The inlet of the first cooling trap was thermostated to the test temperature. At each test temperature, three determinations were made, each at a different flow rate to ensure saturation control. If the determined vapour pressures did not differ more than the estimated reproducibility of the method, the saturation of the gas stream was ensured.
After the collecting time, the cooling traps were removed. The transported test substance was dissolved in a solvent and the amount was quantitatively determined by HPLC with external standard calibration. From the amount of transported test substance, the test temperature and the volume of nitrogen, the vapour pressure was calculated according to the ideal gas law.
A vapour pressure of 35 Pa at 25 °C was determined for the test substance.
Key value for chemical safety assessment
- Vapour pressure:
- 35 Pa
- at the temperature of:
- 25 °C
Additional information
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