Registration Dossier
Registration Dossier
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EC number: 500-425-6 | CAS number: 159034-91-0 1 - 6.5 moles ethoxylated
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
No experimental toxicokinetic study is available on Diethylamine modified ethoxylated trimethylolpropane triacrylate. However, as per REACH guidance document R7. C (2012), information on absorption, distribution, metabolism and excretion may be deduced from the physicochemical properties. Based on these data, Diethylamine modified ethoxylated trimethylolpropane triacrylate could be well absorbed after oral, dermal or inhalation exposure.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
No experimental toxicokinetic study is available on Diethylamine modified ethoxylated trimethylolpropane triacrylate. However, as per REACH guidance document R7. C (2012), information on absorption, distribution, metabolism and excretion may be deduced from the physicochemical properties, including:
-Molecular weight (mean): 413.52 g/mol
-Water solubility: 58.8 g/L (20°C)
-Partition coefficient Log Kow: 1.05-1,86 (20°C)
-Vapour pressure: 0.000 126 Pa (20°C)
ABSORPTION
The value of log Kow (between -1 and 4) and the water solubility are favourable of absorption from the gastro-intestinal tract subsequent to oral ingestion. Even if no systemic effect or mortality was observed in rats treated at 2000 mg/kg bw by gavage, severe clinical signs were observed in the 28-day repeated toxicity study at the highest dose (1000 mg/kg/day). Indeed, Diethylamine modified ethoxylated trimethylolpropane triacrylate seems to be absorbed by oral route.
The value of log Kow (between -1 and 4) and the water solubility are favourable of absorption after dermal exposure. Moreover, the acrylates are known to bind to skin components, and this binding decreases their dermal absorption. Indeed, in the dermal acute toxicity study, no systemic effect or mortality was observed in rats treated at 2000 mg/kg bw. However, Diethylamine modified ethoxylated trimethylolpropane triacrylate showed a strong allergic reaction in the LLNA.
Based on the low value of the vapour pressure, Diethylamine modified ethoxylated trimethylolpropane triacrylate is not a volatile substance. However, based on the chemical data on the substance, absorption after inhalation exposure could be expected.
DISTRIBUTION and METABOLISM
The molecule is lipophilic (log Kow>0), it is likely to distribute into cells and the intracellular concentration may be higher than extracellular concentration particularly in fatty tissues.
No specific data is available on the metabolism of Diethylamine modified ethoxylated trimethylolpropane triacrylate.
ELIMINATION
Due to the good water solubility, the substance could be excreted by urine.
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