Registration Dossier
Registration Dossier
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EC number: 939-693-8 | CAS number: 1268005-68-0
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles, acceptable for assessment Adopted according to OECD SIDS or other official EU regulation procedures (public available peer reviewed source).
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Reference Type:
- secondary source
- Title:
- SIDS Category of Alkyl sulfates, Alkane sulfonates and Alpha-olefin sulfonates
- Author:
- OECD
- Year:
- 2 007
- Bibliographic source:
- UNEP Publications
Materials and methods
- Principles of method if other than guideline:
- Method: other: Unilever in-house protocol
- GLP compliance:
- no
- Type of study:
- guinea pig maximisation test
Test material
- Reference substance name:
- 85586-07-8 (purity 29.9%)
- IUPAC Name:
- 85586-07-8 (purity 29.9%)
- Details on test material:
- - Name of test material (as cited in study report): Trade name
- Physical state: No data
- Analytical purity: 29.9% a.i.
- Lot/batch No.: No data
- Storage condition of test material: No data
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
Study design: in vivo (non-LLNA)
Induction
- Vehicle:
- other: intradermal injection: saline; topical application: distilled water
Challenge
- Vehicle:
- other: intradermal injection: saline; topical application: distilled water
- No. of animals per dose:
- 10
- Details on study design:
- 1st application: Induction 0.08% intracutaneous
2nd application: Induction 0.5% occlusive epicutaneous
3rd application: Challenge 0.1% occlusive epicutaneous
Results and discussion
Any other information on results incl. tables
0/10 guinea pigs sensitised after 2 challenges
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
