Registration Dossier
Registration Dossier
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EC number: 231-166-4 | CAS number: 7440-58-6
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Description of key information
Not required
Link to relevant study records
- Endpoint:
- toxicity to reproduction
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
- Reproductive effects observed:
- not specified
Reference
Effect on fertility: via oral route
- Endpoint conclusion:
- no study available
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
Based on the same behavior and toxicological effects, and their very low systemic absorption, a read across with Zr/ZrO2 is performed.
Overall, the available repeated dose toxicity data indicate that Zr is a metal with an extremely poor potential for causing long-term toxicity. Further, the available results do not suspect Zr of being toxic for reproduction, as no long-term effects on reproductive organs have been observed in any of the available studies.
A testing proposal according to OECD 414 was judged relevant by ECHA. Once the results of the ZrO2 test are available, an update of the Hf dossier will be made.
Short description of key information:
Based on the same behaviour and toxicological effects, and their very low systemic absorption, a read across with ZrO2 is performed.
A testing proposal according to OECD 414 was judjed relevant by ECHA. Once the results of the ZrO2 test is available, an update of the Hf dossier will be made. If no effect is observed on the teratogenicity study, the two-generation reproductive study will not be initiated.
Effects on developmental toxicity
Description of key information
Due to tonnage band, study for developmental toxicity is not required for this dossier.
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Based on the available data, the substance was not classified under the CLP Regulation 1272/2008 and the directive Classification and Labeling 67/548/EC.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
