Registration Dossier
Registration Dossier
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EC number: 203-383-4 | CAS number: 106-31-0
Endpoint summary
Administrative data
Description of key information
Additional information
Hydrolysis study data, provided in section 5.1.2 will be used to demonstrate that butyric anhydride in an aqueous environment will undergo almost immediate hydrolysis to butyric acid. Thus, study data from butyric acid or other similar acids will be used to satisfy all required data points in section 6, as water will be present in all of the studies.
Valid experimental data are available for the endpoints 6.1.1 - short-term toxicity to fish, 6.1.3 - Short-term toxicity to aquatic invertebrates, 6.1.5 - toxicity to aquatic algae and cyanobacteria and 6.1.7 - Toxicity to microorganisms.
Short-term-toxicity to fish
For butyric acid, valid data regarding the short-term toxicity to fish are not available. The exposure period in the studies located (only 48 or 24 h) does not comply with recent test guideline requirements. To compensate for this lack of data, information resulting from valeric acid as supporting substance is used as substitute.
Supporting substance valeric acid:
In a valid short-term toxicity fish test similar to OECD TG 203, the LC50 of valeric acid was determined to be 77 mg/L (Geiger, 1985).
Butyric acid:
The LC50 for butyric acid will be calculated on bases of the LC50 for valeric acid (Geiger 1985) using the respective molecular weights (88.11 and 102.13).
LC50 for butyric acid is derived as ca. 66.4 mg/L.
Short-term toxicity to aquatic invertebrates
For butyric acid, valid data regarding the short-term toxicity to aquatic invertebrates are not available. In the studies located, the exposure period is only 24 h or they exhibit methodological deficiencies. Thus, they do not comply with recent test guideline requirements. To compensate for this lack of data, information resulting from isobutyric acid as supporting substance is used as substitute.
Supporting substance isobutyric acid:
in a valid Daphnia acute immobilization test similar to OECD TG 202, the EC50 of isobutyric acid was determined to be 51,25 mg/L (BASF AG, 1989).
Butyric acid:
As molecular weights of butyric acid and isobutyric acid are equal, the EC50 determined for isobutyric acid can be taken unchanged for butyric acid.
EC50 = 51 mg/L
Toxicity to aquatic algae and cyanobacteria
Valid data regarding the toxicity of butyric acid to aquatic algae and cyanobacteria are not available. To compensate for this lack of data, information resulting from isobutyric acid as supporting substance is used as substitute.
Supporting substance isobutyric acid:
In a valid growth inhibition test with green algae similar to OECD TG 201, the EC50 of isobutyric acid was determined to be 45.1 mg/L (BASF AG, 1990).
Butyric acid
As molecular weights of butyric acid and isobutyric acid are equal, the EC50 determined for isobutyric acid can be taken unchanged for butyric acid.
EC50 = 45.1 mg/L
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