Registration Dossier
Registration Dossier
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EC number: 231-293-5 | CAS number: 7486-38-6
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Based on the absence of data on long-term toxicity towards aquatic invertebrates, a read-across approach with adipic acid is applied. The long-term toxicity of adipic acid to aquatic invertebrates revealed a 21d-NOEC of 6.3 mg/l.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 6.3 mg/L
Additional information
For disodium adipate no data on long-term toxicity towards aquatic
invertebrates are available. Therefore, data of the corresponding acid
are taken into account for assessment and a read-across approach is
applied, based on the following justification.In aqueous media, disodium
adipate and adipic acid acid dissociate into the corresponding anion
(1,6-hexandioic acid ion) and the sodium ion and hydrogen ion (proton),
respectively. Fate, behavior and the ecotoxicological properties of
adipic acid and its disodium salt are thought to be an effect of the
di-carboxylate ion rather than of the sodium ion or the hydrogen ion
(proton), which are normal constituents in environmental systems and
have no relevant ecotoxic properties in low concentrations.
Therefore a read-across between disodium adipate and adipic acid is
justified.
The long-term toxicity of adipic acid to aquatic invertebrates was determined in a test condicted according to OECD Guideline 211 (Daphnia magna Reproduction Test) by the National Institute of Technology and Evaluation, Japan. A 21d-NOEC of 6.3 mg/L was obtained. (MITI, 2002).
Since no details on analytical monitoring are given, it is assumed that the results relate to nominal concentrations, based on test substance concentrations. Any information on pH during the test was not reported. Regarding the effect concentrations, pH effects can be excluded, due to the low range of concentrations.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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