2-tetradecyloctadecan-1-ol

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

October/November 1989

Reliability:

2 (reliable with restrictions)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1989

Report date:

1989

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

The Epictuantest is used for the evidence of a primary skin irritation respectively of a contact allergy caused by epicutanous contact, locally and temporally limited.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-decyltetradecanol

EC Number:

261-385-0

EC Name:

2-decyltetradecanol

Cas Number:

58670-89-6

Molecular formula:

C24H50O

IUPAC Name:

2-decyltetradecan-1-ol

Constituent 2

Details on test material:

- Name of test material (as cited in study report): Isofol 24
- Lot/batch No.: 12840
no more details mentioned

Specific details on test material used for the study:

Different guerbet alcohols were tested:
Isofol 12: 2-butyloctan-1-ol
Isofol 16: 2-hexyldecan-1-ol
Isofol 18 T: Reaction mass of 2-hexyldecan-1-ol and 2-hexyldodecan-1-ol and 2-octaldecan-1-ol and 2-octyldodecan-1-ol
Isofol 18 E: Reaction mass of 2-hexyldodecan-1-ol and 2-octyldecan-1-ol
Isofol 20: 2-octyldodecan-1-ol
Isofol 24: 2-decyltetradecan-1-ol

Test animals

Species:

other: human

Test system

Type of coverage:

semiocclusive

Preparation of test site:

not specified

Vehicle:

unchanged (no vehicle)

Controls:

not required

Duration of treatment / exposure:

For the examination an usual plaster treated with the test substance is fixed on the clinically intact skin. After 24 hours the test plaster is removed and the test area of the skin is examined.

Observation period:

48 and 72 hours

Number of animals:

50 test persons thereof 8 allergic persons

Details on study design:

Epicutan test

Results and discussion

In vivo

Results

Irritation parameter:

other:

Remarks on result:

no indication of irritation

Any other information on results incl. tables

All Guerbet alcohols did not show any indication for a primary irritation or the outbreak of an already existing allergy against the product itself or on any impurity in the human test panel.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Remarks:

Migrated information Criteria used for interpretation of results: expert judgment

Conclusions:

Based on the results of this study different guerbet alcohols are not irritating to the skin of humans.

Executive summary:

Based on the results of this study different guebet alsocohls are not irritating to the skin of humans.