Registration Dossier
Registration Dossier
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EC number: 206-768-5 | CAS number: 373-61-5
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
BASF (1995) reported about the skin irritation/corrosion properties of a dihydrogen bis(acetato-O)difluoroborate (used as a 40% concentration). Rabbits were covered semiocclusive with the undiluted test substance for 3 minutes and 1 hour. Results after 3 minutes exposure: A mean value for erythema could not be calculatead, because in one animal visual necrosis was observed 24 hours after removal of the test patch. Thus, the observation period for this rabbit was terminated after 72 hours. The macroscopic lesion of the skin was assessed by pathological examination, which revealed superficial necrosis. The skin findings (such as erythema and edema) were reversible in one animal within 15 days, while erythema was still present in another animal at study termination. Results after 1 hour exposure: Visual necrosis was observed in the animal after removal of the patch. Due to severe corrosion, the observation peroid was terminated after 48 hours. The macroscopic lesion of the skin was assessed by histopathological examination, which revealed severe necrosis from the coagulation type (full-thickness necrosis).
In an older BASF study (1978) the rabbits were covered occlusive with the unchanged test article for 1 min, 5 min, 15 min and 20 hours. Slight necrosis was already observed after 1 and 5 min and severe skin lesions were observed 15 minutes after application. Due to human reasons, both animals were killed one day after application.
As the product corrodes the skin, it can be expected to have a similar effect on the eyes, also. This assumption was confirmed by an eye irritation test (BASF, 1978).
Justification for classification or non-classification
Classification proposal: C: R35 (EU); Skin Corr. 1A: H314 (GHS).
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