Registration Dossier
Registration Dossier
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EC number: 207-306-5 | CAS number: 460-19-5
Respiratory sensitisation
Administrative data
- Endpoint:
- respiratory sensitisation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
Materials and methods
- Principles of method if other than guideline:
- 6-month whole body inhalation exposure
- GLP compliance:
- no
Test material
- Reference substance name:
- Oxalonitrile
- EC Number:
- 207-306-5
- EC Name:
- Oxalonitrile
- Cas Number:
- 460-19-5
- Molecular formula:
- C2N2
- IUPAC Name:
- carbononitridic cyanide
- Test material form:
- gas
Constituent 1
- Specific details on test material used for the study:
- ethanedinitrile 99%
Test animals
- Species:
- other: albino rat and Rhesus monkey
- Strain:
- other: Charles River Sprague-Dawley COBS and Maccaca mulatta
- Sex:
- male
Test system
- Vehicle:
- other: air
- Concentration:
- 0, 11 and 25 ppm
- No. of animals per dose:
- rats: 30 per exposure group
monkeys: 5 per exposure group - Negative control substance(s):
- other: air
Results and discussion
- Results:
- No sensitisation was observed during 180 days of exposure and postexposure period.
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP criteria not met
- Conclusions:
- No sensitisation was observed during 180 days of exposure and postexposure period.
- Executive summary:
No sensitisation was observed during 180 days of exposure and postexposure period of rats and monkeys with sublethal concentrations of ethanedinitrile (11 and 25 ppm).
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