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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from publication

Data source

Reference
Reference Type:
publication
Title:
Monographs on Fragrance Raw Materials: l-Carvone.
Author:
D. L. J. Opdyke
Year:
1973
Bibliographic source:
Food and Cosmetics Toxicology, Volume 11, Issue 6, December 1973, Pages 1057-1058.

Materials and methods

Objective of study:
metabolism
Test guideline
Qualifier:
according to guideline
Guideline:
other: as below
Principles of method if other than guideline:
In vivo Metabolism study of l-carvone in rabbit
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
L-p-mentha-1(6),8-dien-2-one
EC Number:
229-352-5
EC Name:
L-p-mentha-1(6),8-dien-2-one
Cas Number:
6485-40-1
Molecular formula:
C10H14O
IUPAC Name:
(5R)-2-methyl-5-(prop-1-en-2-yl)cyclohex-2-en-1-one
Test material form:
liquid
Details on test material:
- IUPAC Name: L-p-mentha-1(6),8-dien-2-one
- Common Name: L-carvone
- InChI:1S/C10H14O/c1-7(2)9-5-4-8(3)10(11)6-9/h4,9H,1,5-6H2,2-3H3/t9-/m1/s1
- Smiles:C1[C@@H](CC=C (C1=O)C)C(C)=C
- Molecular formula : C10H14O
- Molecular weight : 150.2196 g/mol
- Substance type: organic
- Physical state: Colorless liquid
Specific details on test material used for the study:
- IUPAC Name: L-p-mentha-1(6),8-dien-2-one
- Common Name: L-carvone
- InChI:1S/C10H14O/c1-7(2)9-5-4-8(3)10(11)6-9/h4,9H,1,5-6H2,2-3H3/t9-/m1/s1
- Smiles:C1[C@@H](CC=C (C1=O)C)C(C)=C
- Molecular formula : C10H14O
- Molecular weight : 150.2196 g/mol
- Substance type: organic
- Physical state: Colorless liquid
Radiolabelling:
not specified

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
not specified
Vehicle:
not specified
No. of animals per sex per dose / concentration:
not specified
Control animals:
not specified
Positive control reference chemical:
not specified
Details on study design:
not specified
Details on dosing and sampling:
not specified
Statistics:
not specified

Results and discussion

Preliminary studies:
not specified
Main ADME results
Type:
metabolism
Results:
Carvone was metabolized to 1,5-dimethyl-l,5-hexadien-l,6-dicarboxylic acid and a carbinol in which one ethylene linkage was saturated and the keto group was reduced.

Toxicokinetic / pharmacokinetic studies

Details on absorption:
not specified
Details on distribution in tissues:
not specified
Details on excretion:
not specified

Metabolite characterisation studies

Metabolites identified:
yes
Details on metabolites:
1,5-dimethyl-l,5-hexadien-l,6-dicarboxylic acid

Applicant's summary and conclusion

Conclusions:
Low bio-accumulation potential based on study results
Executive summary:

Available data pertaining to the in-vivo Metabolism of the chemical l-Carvone suggests metabolism of l-Carvone to 1,5 -dimethyl-l,5 -hexadien-l,6 - dicarboxylic acid and a carbinol in which one ethylene linkage was saturated and the keto group was reduced.Thus, there is no evidence that they or their metabolites would accumulate in tissues and cause a concern for consumer safety. Also, the use in fragrances in the USA, amounts to less than 2000 lb/yr. Hence it is concluded that l-Carvone is likely to exhibit low bio-accumulation potential based on study results and use.