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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Link to relevant study records
Reference
Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6
Qualifier:
according to guideline
Guideline:
other: Estimated data
Principles of method if other than guideline:
Prediction is done using QSAR Toolbox version 2.3.
GLP compliance:
no
Type of study:
guinea pig maximisation test
Species:
guinea pig
Strain:
not specified
Sex:
not specified
Route:
other: no data
Vehicle:
no data
Route:
other: no data
Vehicle:
no data
Positive control substance(s):
not specified
Group:
test chemical
Clinical observations:
Not sensitising
Remarks on result:
other: Group: test group. Clinical observations: Not sensitising.





The prediction was based on dataset comprised from the following descriptors: "Skin sensitisation"
Estimation method: Taking highest mode value from the 5 nearest neighbours
Domain logical expression:Result: In Domain

(("a" and "b" ) and ("c" and "d" ) )

Domain logical expression index: "a"

Similarity boundary:Target: c1(S(=O)(=O)CCO)ccc(NC(C)=O)cc1
Threshold=50%,
Dice(Atom pairs)

Domain logical expression index: "b"

Similarity boundary:Target: c1(S(=O)(=O)CCO)ccc(NC(C)=O)cc1
Threshold=60%,
Dice(Atom pairs)

Domain logical expression index: "c"

Parametric boundary:The target chemical should have a value of log Kow which is >= -1.25

Domain logical expression index: "d"

Parametric boundary:The target chemical should have a value of log Kow which is <= 0.354

Interpretation of results:
not sensitising
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
According to the quantitative structure activity relationship model prediction, N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide was predicted as not being sensitizing to guinea pig skin by Guinea pig maximisation test.
Executive summary:

According to the quantitative structure activity relationship model prediction, N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide was predicted as not being sensitizing to guinea pig skin by Guinea pig maximisation test.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

According to the quantitative structure activity relationship model prediction, N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide was predicted as not being sensitizing to guinea pig skin by Guinea pig maximisation test.


Migrated from Short description of key information:
Not sensitising (Negative) estimation values have been obtained for N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide.

Justification for selection of skin sensitisation endpoint:
The K2 level estimation study has been considered for sensitization effect and according to the QSAR model prediction, N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide was predicted as not being sensitizing to the guinea pig skin.

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

Not sensitising (Negative) estimation values have been obtained for N-[4-[(2-hydroxyethyl) sulphonyl] phenyl]acetamide. Thus, the chemical is considered to be non-sensitizing.