N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide

Repeated dose toxicity: oral

Administrative data

Endpoint:

sub-chronic toxicity: oral

Type of information:

(Q)SAR

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Justification for type of information:

QSAR prediction: migrated from IUCLID 5.6

Data source

Reference

Reference Type:

other: Predicted data

Title:

R: QSAR Toolbox 2.3.0.1132 prediction for "Effect LOEL" read across evaluation for 27375-52-6

Author:

Sustainability Support Services (Europe) AB

Year:

2012

Bibliographic source:

QSAR Toolbox version 2.3

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 408 (Repeated Dose 90-Day Oral Toxicity Study in Rodents)

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide

EC Number:

248-433-6

EC Name:

N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide

Cas Number:

27375-52-6

Molecular formula:

C10H13NO4S

IUPAC Name:

N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide

Details on test material:

- Name of test material (as cited in study report): N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide
- Substance type: Organic
- Physical state: Solid

Test animals

Species:

rat

Strain:

Fischer 344

Sex:

male/female

Administration / exposure

Route of administration:

oral: drinking water

Vehicle:

not specified

Duration of treatment / exposure:

90 days

Control animals:

not specified

Results and discussion

Results of examinations

Body weight and weight changes:

effects observed, treatment-related

Description (incidence and severity):

Body weight decreased

Effect levels

Dose descriptor:

LOEL

Effect level:

1 738.437 other: mg/kg/day

Based on:

test mat.

Sex:

male/female

Basis for effect level:

other: Effect : Body weight decreased

Target system / organ toxicity

Critical effects observed:

not specified

Any other information on results incl. tables

The prediction was based on dataset comprised from the following descriptors: "effect LOEL"
Estimation method: Taking average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain

("a" and ("b" and "c" ) )

Domain logical expression index: "a"

Similarity boundary:Target: c1(S(=O)(=O)CCO)ccc(NC(C)=O)cc1
Threshold=50%,
Dice(Atom pairs)

Domain logical expression index: "b"

Parametric boundary:The target chemical should have a value of log Kow which is >= -0.967

Domain logical expression index: "c"

Parametric boundary:The target chemical should have a value of log Kow which is <= 1.27

Applicant's summary and conclusion

Conclusions:

Repeated dose toxicity LOEL (Lowest observed effect level) of N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide to rat by the oral route was estimated at a dose concentration of 1738.437 mg/kg bw/day.On the basis of this LOEL value it is concluded that the test substance is not toxic to rat by oral route below the above mentioned dose.

Executive summary:

Repeated dose toxicity LOEL (Lowest observed effect level) of N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide to rat by the oral route was estimated at a dose concentration of 1738.437 mg/kg bw/day.On the basis of this LOEL value it is concluded that the test substance is not toxic to rat by oral route below theabove mentioned dose.

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