Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
May, 2010
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: According to the prediction of toxicity delivered by the software Tox Boxes 2.9, Acute Toxicity overview indicates value with moderate/borderline reliability index.
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2010
Report date:
2010

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
In silico prediction.
Tox Boxes 2.9 is the in house software for the prediction of basic toxicity endpoints in chemicals. Predictions are made
analyzing the chemical structure and based upon large validated databases and QSAR models, in combination with expert
knowledge of organic chemistry and toxicology.
GLP compliance:
no
Test type:
other: In silico prediction.

Test material

Constituent 1
Chemical structure
Reference substance name:
2-methylpropyl 1-benzyl-1H-indazole-3-carboxylate
Cas Number:
1185130-06-6
Molecular formula:
C19H20N2O2
IUPAC Name:
2-methylpropyl 1-benzyl-1H-indazole-3-carboxylate

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 200 mg/kg bw

Applicant's summary and conclusion

Conclusions:
According to the prediction of toxicity delivered by ToxBoxes 2.9, Acute toxicity overwiew indicates moderate/borderline reliability index for LD50 value of 1200 mg/kg.