Registration Dossier
Registration Dossier
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EC number: 206-200-6 | CAS number: 307-35-7
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- August, 2000
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- GLP compliance:
- yes
- Test type:
- standard acute method
Test material
- Reference substance name:
- Heptadecafluorooctanesulphonyl fluoride
- EC Number:
- 206-200-6
- EC Name:
- Heptadecafluorooctanesulphonyl fluoride
- Cas Number:
- 307-35-7
- Molecular formula:
- C8F18O2S
- IUPAC Name:
- heptadecafluorooctane-1-sulfonyl fluoride
- Details on test material:
- Identification: RM90
Characteristics: liquid
Density: 1.845 g/mL
Storage conditions: at room temperature
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 hour
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No animals died during the study, The LD50 was not calculated and it was considered to be higher than 2000mg/kg.
- Clinical signs:
- other: No general or local clinical abnormalities were seen in any animal.
- Gross pathology:
- No appreciable changes were evident in the treated animals of either sex at the autopsy carried out at the end of the observation period.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In conclusion, the test article RM90, when administered by dermal route to the rat, did not cause mortality or show appreciable toxic effects at the limit dose of 2000mg/kg. The LD50 by dermal route is considered to be higher than 2000mg/kg.
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